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- Title
IL-17 和VEGF在慢性鼻-鼻窦炎患者鼻息肉组织中的表达 及相关性研究.
- Authors
武颖异; 包亚军; 周雯娟; 耿莉莉; 程友
- Abstract
Objective: To investigate the expression of interleukin-17 (1L-17) and vascular endothelial growth factor (VEGF) in nasal polyp tissue of patients with chronic rhinosinusitis. and to analyze the correlation between IL-17 and VEGF expression levels. Methods: 95 patients with chronic rhinosinusitis who were treated in our hospital from January 2015 to December 2017 were selected as the research subjects. According to whether the patients had nasal polyps, they were divided into nasal polyps (Observation group 1) with 49 cases and no nasal polyps (Observation group 2) with 46 cases, hi addition. 40 patients with nasal septum deviation who were treated in our hospital over the same period were selected as control group. All patients were underwent endoscopic surgery.and the nasal concha mucous membrane at the narrower side of patients was taken as a test specimen during the operation. The expression levels of IL-17 and VEGF in all tissue specimens were detected by immunohistochemical SP method, and the correlation of IL-17 and VEGF expression levels was analyzed. Results: The positive rates of IL-17 and VEGF in Observation group 1 were 93.88% (46.49) and 85.71% (42/49). respectively, which were all higher than those of [76.09% (35/46). 65.22% (30/46)] in Observation group 2 and [5.00% (2 40) and 2.50% 11 401] m the control group, the differences were statistically significant (P 0.05). The expression levels of IL-17 mid VEGF in Observation group 1 were (38.92± 5.34)amountLPand (33.21± 4.87)aniountLP, respectively, which were all higher than those of [(28.19± 4.56)aniountLP,(21.28± 4.03)aniountLP] in Observation group 2 and[(9.31± 2.76)amountLP, (7.19± 1.95)aniountLP] in the control group, the differences were statistically significant (P<0.05). The results of Spearman correlation analysis showed that there was a positive correlation between die expression levels of IL-17 and VEGF of patients in Observation group 1 and Observation group 2 (P<0.05). Conclusion: The expression of IL-17 and VEGF in the nasal polyp tissue of patients with chronic rhinosinusitis is increased significantly, and the expression level of IL-17 is significantly positively correlated with VEGF expression, it is suggested mat IL-17 and VEGF may participate in the occurrence and development of nasal polyps.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 10, p1901
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.10.019