We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog.
- Authors
Poli, Federica; Calistri, Maurizio; Mandara, Maria Teresa; Baroni, Massimo
- Abstract
An 8-yr-old French Bulldog was presented with a non-ambulatory tetraparesis. Magnetic resonance showed an intradurally located mass at the level of the right second cervical nerve root. The mass was surgically removed and the dog was ambulatory within 4 d. A 10-mo post-surgical imaging follow-up revealed a recurrence of the primary mass and another intradural/intramedullary mass at the level of the first thoracic vertebral body. Overall histological features were suggestive of malignant peripheral nerve sheath tumor (MPNST) for both masses. Immunohistochemistry was found weak but diffusely positive for S-100 and neurono-specific enolase for both masses. A diagnosis of primary MPNST for the cervical mass and of metastasis for the thoracic mass was made, possibly disseminated via the subarachnoidal space. To our knowledge, the central nervous system metastasis of MPNSTs has not previously been reported in dogs. The clinician should be aware that these tumors, albeit rarely, can metastasize to the central nervous system.
- Subjects
SCHWANNOMAS; CENTRAL nervous system; PERIPHERAL nervous system; CERVICAL plexus
- Publication
Open Veterinary Journal, 2019, Vol 9, Issue 1, p49
- ISSN
2226-4485
- Publication type
Article
- DOI
10.4314/ovj.v9i1.9