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- Title
Reduction in microalbuminuria by calcium channel blockers in patients with type 2 diabetes mellitus and hypertension-A randomized, open-label, active-controlled, superiority, parallel-group clinical trial.
- Authors
Hwang, You ‐ Cheol; Yoon, Kun ‐ Ho; Cha, Bong ‐ Soo; Lee, Kwan ‐ Woo; Jang, Hak Chul; Min, Kyung Wan; Chung, Choon Hee; Lee, Moon ‐ Kyu; Hwang, You-Cheol; Yoon, Kun-Ho; Cha, Bong-Soo; Lee, Kwan-Woo; Lee, Moon-Kyu
- Abstract
<bold>Background: </bold>It has been suggested that renoprotection with calcium channel blockers (CCBs) may differ. This study aimed to compare the anti-proteinuric effect of different CCBs in patients with type 2 diabetes (T2D).<bold>Methods: </bold>A multicentre, randomized, open-label, active-controlled study was performed in seven centres in Korea. A total of 74 patients with T2D and microalbuminuria treated with renin-angiotensin system (RAS) blockers were randomized to a cilnidipine 10 mg treatment (n=38) or amlodipine 5 mg treatment (n=36).<bold>Results: </bold>Urine albumin to creatinine ratio (ACR) reduction was similar between the two groups at 12 weeks (-53.0±123.2 mg/g in cilnidipine group and -35.7±83.6 mg/g in amlodipine group, P=.29) or 24 weeks (-57.3±106.9 mg/g in cilnidipine group and -20.0±110.4 mg/g in amlodipine group, P=.24). In a subgroup analysis, cilnidipine treatment showed a larger ACR reduction than amlodipine treatment at 12 weeks (-84.7±106.8 mg/g in cilnidipine group and -9.5±79.2 mg/g in amlodipine group, P=.01) and 24 weeks (-84.0±111.7 mg/g in cilnidipine group and 14.6±119.4 mg/g in amlodipine group, P=.008), particularly in patients with a longer duration of diabetes more than 10 years.<bold>Conclusions: </bold>Cilnidipine did not show any additional anti-albuminuric effect compared with amlodipine in patients with T2D and microalbuminuria treated with an RAS blocker. However, the anti-albuminuric effect of cilnidipine might differ according to the duration of diabetes.
- Publication
International Journal of Clinical Practice, 2017, Vol 71, Issue 9, pn/a
- ISSN
1368-5031
- Publication type
journal article
- DOI
10.1111/ijcp.12987