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- Title
Homocysteine, vitamin B<sub>12</sub>, folate and cognitive functions: a systematic and critical review of the literature.
- Authors
Vogel, T.; Dali-Youcef, N.; Kaltenbach, G.; Andrès, E.
- Abstract
Elevated serum homocysteine, decreased folate and low vitamin B12 serum levels are associated with poor cognitive function, cognitive decline and dementia. Despite evidence of an epidemiological association, randomised controlled trials did not provide any clear evidence so far that supplementation with vitamin B12 and/or folate improves dementia or slows cognitive decline, even though it might normalise homocysteine levels. In this report, we review the current knowledge on the relationship between homocysteine, folate and vitamin B12 levels and the way their disruption influences cognitive function in adults.
- Publication
International Journal of Clinical Practice, 2009, Vol 63, Issue 7, p1061
- ISSN
1368-5031
- Publication type
Article
- DOI
10.1111/j.1742-1241.2009.02026.x