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- Title
Interleukin-37 Mediates the Antitumor Activity in Hepatocellular Carcinoma: Role for CD57+ NK Cells.
- Authors
Jing-Jing Zhao; Qiu-Zhong Pan; Ke Pan; De-Sheng Weng; Qi-Jing Wang; Jian-Jun Li; Lin Lv; Dan-Dan Wang; Hai-Xia Zheng; Shan-Shan Jiang; Xiao-Fei Zhang; Jian-Chuan Xia
- Abstract
The biological role of interleukin-37 (IL-37) in cancer is large unknown. Through immunohistochemical detection using 163 primary hepatocellular carcinoma (HCC) clinical specimens, we found the expression of IL-37 was decreased in tumor tissues, and the expression level was negatively correlated with tumor size. High expression of IL-37 in HCC tumor tissues was associated with better overall survival (OS) and disease-free survival (DFS). IL-37 expression in tumor tissues was positively associated with the density of tumor-infiltrating CD571natural killer (NK) cells, but not with the CD31and CD81T cells. Consistently, in vitro chemotaxis analysis showed that IL-37- overexpressing HCC cells could recruit more NK cells. The in vivo mouse model experiments also revealed that overexpression IL-37 in HCC cells significantly delayed tumor growth and recruited more NK cells into tumors tissues. Our finding suggested that IL-37 might play an important role for the prognosis of HCC patients via regulating innate immune-action.
- Subjects
INTERLEUKINS; LIVER cancer; KILLER cells; TUMOR growth; CHEMOTAXIS
- Publication
Scientific Reports, 2014, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep05177