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- Title
Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson's Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain Stimulation.
- Authors
Meng, Fangang; Cen, Shanshan; Yi, Zhiqiang; Li, Weiguo; Cai, Guoen; Wang, Feng; Quintin, Stephan S.; Hey, Grace E.; Hernandez, Jairo S.; Han, Chunlei; Fan, Shiying; Gao, Yuan; Song, Zimu; Yi, Junfei; Wang, Kailiang; Zhang, Liangwen; Ramirez-Zamora, Adolfo; Zhang, Jianguo
- Abstract
Deep brain stimulation (DBS) is an effective treatment for dyskinesia in patients with Parkinson's disease (PD), among which the therapeutic targets commonly used include the subthalamic nucleus (STN) and the globus pallidus internus (GPi). Levodopa-induced dyskinesia (LID) is one of the common motor complications arising in PD patients on chronic treatment with levodopa. In this article, we retrospectively evaluated the outcomes of LID with the Unified Dyskinesia Rating Scale (UDysRS) in patients who underwent DBS in multiple centers with a GPi or an STN target. Meanwhile, the Med off MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS-Ⅲ) and the levodopa equivalent daily dose (LEDD) were also observed as secondary indicators. PD patients with a GPi target showed a more significant improvement in the UDysRS compared with an STN target (92.9 ± 16.7% vs. 66.0 ± 33.6%, p < 0.0001). Both the GPi and the STN showed similar improvement in Med off UPDRS-III scores (49.8 ± 22.6% vs. 52.3 ± 29.5%, p = 0.5458). However, the LEDD was obviously reduced with the STN target compared with the GPi target (44.6 ± 28.1% vs. 12.2 ± 45.8%, p = 0.006).
- Subjects
SUBTHALAMIC nucleus; DEEP brain stimulation; PARKINSON'S disease; BRAIN stimulation; DYSKINESIAS; GLOBUS pallidus
- Publication
Brain Sciences (2076-3425), 2022, Vol 12, Issue 8, p1054
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci12081054