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- Title
Antenatal corticosteroids and perinatal outcome in late fetal growth restriction: analysis of prospective cohort.
- Authors
Familiari, A.; Napolitano, R.; Visser, G. H. A.; Lees, C.; Wolf, H.; Prefumo, F.; Arabin, B.; Berger, A.; Bergman, E.; Bhide, A.; Bilardo, C. M.; Breeze, A. C.; Brodszki, J.; Calda, P.; Cesari, E.; Cetin, I.; Derks, J. B.; Ebbing, C.; Ferrazzi, E.; Frusca, T.
- Abstract
<bold>Objective: </bold>The aim of this study is to evaluate the possible role of antenatal administration of corticosteroids for fetal lung maturation on short term perinatal outcomes in late FGR.<bold>Methods: </bold>This cohort study is a secondary analysis of a multicenter prospective observational study, the TRUFFLE-2 feasibility study, conducted between 2017 and 2018 in 33 European perinatal centers. We included women with singleton pregnancy from 32+0 to 36+6 weeks of gestation with a fetus considered at risk for FGR, defined as estimated fetal weight (EFW) or abdominal circumference (AC) <10th centile, or umbilico-cerebral ratio (UCR) >95th centile, or a fall of more than 40 centile points in AC measurement from the 20 weeks scan. The primary adverse outcome was a composite of abnormal condition at birth or major neonatal morbidity.<bold>Results: </bold>A total of 86 pregnancies who received antenatal corticosteroids (exposed) were matched with non-exposed pregnancies. Both groups were similar regarding gestational age at inclusion (33 weeks), EFW (1673 g) and UCR (0.68), gestational age at delivery (35.5 weeks) and birth weight (1925 g); the presented values are for both groups combined. No significant differences were observed between exposed and non-exposed for composite adverse outcome (28% vs. 24%; p=0.73) or for any of its elements.<bold>Conclusion: </bold>The present data do not show a beneficial effect of steroids on short term outcomes in fetuses with late FGR. This article is protected by copyright. All rights reserved.
- Subjects
JOHN Wiley &; Sons Inc.; FETAL growth retardation; PREGNANCY outcomes; COHORT analysis; GESTATIONAL age; BIRTH weight; FETAL anoxia
- Publication
Ultrasound in Obstetrics & Gynecology, 2023, Vol 61, Issue 2, p191
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1002/uog.26127