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- Title
NLRP3 inflammasome-induced pyroptosis in digestive system tumors.
- Authors
Jiexia Wen; Bin Xuan; Yang Liu; Liwei Wang; Li He; Xiangcai Meng; Tao Zhou; Yimin Wang
- Abstract
Programmed cell death (PCD) refers to cell death in a manner that depends on specific genes encoding signals or activities. PCD includes apoptosis, pyroptosis, autophagy and necrosis (programmed necrosis). Among these mechanisms, pyroptosis is mediated by the gasdermin family and is accompanied by inflammatory and immune responses. When pathogens or other danger signals are detected, cytokine action and inflammasomes (cytoplasmic multiprotein complexes) lead to pyroptosis. The relationship between pyroptosis and cancer is complex and the effect of pyroptosis on cancer varies in different tissue and genetic backgrounds. On the one hand, pyroptosis can inhibit tumorigenesis and progression; on the other hand, pyroptosis, as a pro-inflammatory death, can promote tumor growth by creating a microenvironment suitable for tumor cell growth. Indeed, the NLRP3 inflammasome is known to mediate pyroptosis in digestive system tumors, such as gastric cancer, pancreatic ductal adenocarcinoma, gallbladder cancer, oral squamous cell carcinoma, esophageal squamous cell carcinoma, in which a pyroptosis-induced cellular inflammatory response inhibits tumor development. The same process occurs in hepatocellular carcinoma and some colorectal cancers. The current review summarizes mechanisms and pathways of pyroptosis, outlining the involvement of NLRP3 inflammasome-mediated pyroptosis in digestive system tumors.
- Subjects
ESOPHAGEAL cancer; PYROPTOSIS; DIGESTIVE organs; APOPTOSIS; NLRP3 protein; GALLBLADDER cancer
- Publication
Frontiers in Immunology, 2023, Vol 14, p01
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2023.1074606