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A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.
Published in:
Diabetologia, 2009, v. 52, n. 6, p. 1056, doi. 10.1007/s00125-009-1285-z
By:
- Kotronen, A.;
- Johansson, L.;
- Roos, C.;
- Westerbacka, J.;
- Hamsten, A.;
- Bergholm, R.;
- Arkkila, P.;
- Arola, J.;
- Kiviluoto, T.;
- Fisher, R.;
- Ehrenborg, E.;
- Orho-Melander, M.;
- Ridderstråle, M.;
- Groop, L.;
- Yki-Järvinen, H.
Publication type:
Article
Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations.
Published in:
Diabetologia, 2009, v. 52, n. 4, p. 684, doi. 10.1007/s00125-009-1282-2
By:
- Kotronen, A.;
- Velagapudi, V.;
- Yetukuri, L.;
- Westerbacka, J.;
- Bergholm, R.;
- Ekroos, K.;
- Makkonen, J.;
- Taskinen, M.-R.;
- Orešič, M.;
- Yki-Järvinen, H.
Publication type:
Article
Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome.
Published in:
Diabetologia, 2008, v. 51, n. 1, p. 130, doi. 10.1007/s00125-007-0867-x
By:
- Kotronen, A.;
- Seppälä-Lindroos, A.;
- Bergholm, R.;
- Yki-Järvinen, H.
Publication type:
Article
Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance.
Published in:
Diabetologia, 2007, v. 50, n. 11, p. 2356, doi. 10.1007/s00125-007-0790-1
By:
- Adiels, M.;
- Westerbacka, J.;
- Soro-Paavonen, A.;
- Häkkinen, A.;
- Vehkavaara, S.;
- Caslake, M.;
- Packard, C.;
- Olofsson, S.;
- Yki-Järvinen, H.;
- Taskinen, M.;
- Borén, J.
Publication type:
Article
Overproduction of large VLDL particles is driven by increased liver fat content in man.
Published in:
Diabetologia, 2006, v. 49, n. 4, p. 755, doi. 10.1007/s00125-005-0125-z
By:
- Adiels, M.;
- Taskinen, M.-R.;
- Packard, C.;
- Caslake, M. J.;
- Soro-Paavonen, A.;
- Westerbacka, J.;
- Vehkavaara, S.;
- Häkkinen, A.;
- Olofsson, S.-O.;
- Yki-Järvinen, H.;
- Borén, J.
Publication type:
Article
Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study.
Published in:
Diabetologia, 2006, v. 49, n. 3, p. 442, doi. 10.1007/s00125-005-0132-0
By:
- Yki-Järvinen, H.;
- Kauppinen-Mäkelin, R.;
- Tiikkainen, M.;
- Vähätalo, M.;
- Virtamo, H.;
- Nikkilä, K.;
- Tulokas, T.;
- Hulme, S.;
- Hardy, K.;
- McNulty, S.;
- Hänninen, J.;
- Levänen, H.;
- Lahdenperä, S.;
- Lehtonen, R.;
- Ryysy, L.
Publication type:
Article
Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects.
Published in:
Diabetologia, 2006, v. 49, n. 1, p. 132, doi. 10.1007/s00125-005-0075-5
By:
- Westerbacka, J.;
- Cornér, A.;
- Kannisto, K.;
- Kolak, M.;
- Makkonen, J.;
- Korsheninnikova, E.;
- Nyman, T.;
- Hamsten, A.;
- Fisher, R.;
- Yki-Järvinen, H.
Publication type:
Article
Increased augmentation of central blood pressure is associated with increases in carotid intima–media thickness in type 2 diabetic patients.
Published in:
Diabetologia, 2005, v. 48, n. 8, p. 1654, doi. 10.1007/s00125-005-1812-5
By:
- Westerbacka, J.;
- Leinonen, E.;
- Salonen, J. T.;
- Salonen, R.;
- Hiukka, A.;
- Yki-Järvinen, H.;
- Taskinen, M.-R.
Publication type:
Article
In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing’s syndrome is associated with increased regeneration of cortisol by 11ß-hydroxysteroid dehydrogenase type 1 in adipose tissue.
Published in:
Diabetologia, 2004, v. 47, n. 10, p. 1668, doi. 10.1007/s00125-004-1508-2
By:
- Sutinen, J.;
- Kannisto, K.;
- Korsheninnikova, E.;
- Nyman, T.;
- Ehrenborg, E.;
- Andrew, R.;
- Wake, D. J.;
- Hamsten, A.;
- Walker, B. R.;
- Yki-Järvinen, H.
Publication type:
Article
Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk Liver fat and insulin resistance.
Published in:
Diabetologia, 2004, v. 47, n. 8, p. 1360, doi. 10.1007/s00125-004-1460-1
By:
- Westerbacka, J.;
- Cornér, A.;
- Tiikkainen, M.;
- Tamminen, M.;
- Vehkavaara, S.;
- Häkkinen, A.-M.;
- Fredriksson, J.;
- Yki-Järvinen, H.
Publication type:
Article
Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance.
Published in:
Diabetologia, 2004, v. 47, n. 6, p. 1118, doi. 10.1007/S00125-004-1417-4
By:
- Gertow, K.;
- Pietiläinen, K. H.;
- Yki-Järvinen, H.;
- Kaprio, J.;
- Rissanen, A.;
- Eriksson, P.;
- Hamsten, A.;
- Fisher, R. M.
Publication type:
Article
Family histories of Type II diabetes and hypertension predict intima–media thickness in patients with Type I diabetes S. Mäkimattila et al.: Predictors of intima–media thickness in Type I diabetes.
Published in:
Diabetologia, 2002, v. 45, n. 5, p. 711, doi. 10.1007/s00125-002-0817-6
By:
- Mäkimattila, S.;
- Ylitalo, K.;
- Schlenzka, A.;
- Taskinen, M.-R.;
- Summanen, P.;
- Syvänne, M.;
- Yki-Järvinen, H.
Publication type:
Article
Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2011, v. 13, n. 4, p. 374, doi. 10.1111/j.1463-1326.2010.01355.x
By:
- Bunck, M. C.;
- Eliasson, B.;
- Cornér, A.;
- Heine, R. J.;
- Shaginian, R. M.;
- Taskinen, M.-R.;
- Yki-Järvinen, H.;
- Smith, U.;
- Diamant, M.
Publication type:
Article
Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2010, v. 12, n. 2, p. 167, doi. 10.1111/j.1463-1326.2009.01173.x
By:
- Vilsbøll, T.;
- Rosenstock, J.;
- Yki-Järvinen, H.;
- Cefalu, W. T.;
- Chen, Y.;
- Luo, E.;
- Musser, B.;
- Andryuk, P. J.;
- Ling, Y.;
- Kaufman, K. D.;
- Amatruda, J. M.;
- Engel, S. S.;
- Katz, L.
Publication type:
Article
Immunohistochemical demonstration of relaxin in gynecologic tumors.
Published in:
1983
By:
- Yki-Järvinen, Hannele;
- Wahlström, Torsten;
- Seppälä, Markku;
- Yki-Järvinen, H;
- Wahlström, T;
- Seppälä, M
Publication type:
journal article
Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.
Published in:
Diabetologia, 2013, v. 56, n. 4, p. 886, doi. 10.1007/s00125-013-2829-9
By:
- Lallukka, S.;
- Sevastianova, K.;
- Perttilä, J.;
- Hakkarainen, A.;
- Orho-Melander, M.;
- Lundbom, N.;
- Olkkonen, V.;
- Yki-Järvinen, H.
Publication type:
Article
Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly.
Published in:
Diabetologia, 2012, v. 55, n. 4, p. 1186, doi. 10.1007/s00125-011-2435-7
By:
- Varewijck, A.;
- Janssen, J.;
- Vähätalo, M.;
- Hofland, L.;
- Lamberts, S.;
- Yki-Järvinen, H.
Publication type:
Article
Type 2 diabetes: remission in just a week.
Published in:
2011
By:
- Yki-Järvinen, H.
Publication type:
Editorial
Efficacy and safety of linagliptin as add-on therapy to basal insulin and metformin in people with Type 2 diabetes.
Published in:
Diabetic Medicine, 2016, v. 33, n. 7, p. 926, doi. 10.1111/dme.13041
By:
- Durán‐Garcia, S.;
- Lee, J.;
- Yki‐Järvinen, H.;
- Rosenstock, J.;
- Hehnke, U.;
- Thiemann, S.;
- Patel, S.;
- Woerle, H.‐J.
Publication type:
Article
Nateglinide combination therapy with basal insulin and metformin in patients with Type 2 diabetes.
Published in:
Diabetic Medicine, 2009, v. 26, n. 4, p. 409, doi. 10.1111/j.1464-5491.2009.02691.x
By:
- Juurinen, L.;
- Tiikkainen, M.;
- Saltevo, J.;
- Nikkil, K.;
- Lanki, H.;
- Leppävuori, E.;
- Kock, T.;
- Teikari-Myyr, T.;
- Kauppinen-Mäkelin, R.;
- Kotronen, A.;
- Yki-Järvinen, H.
Publication type:
Article
Glycaemic control and hypoglycaemia with new insulin glargine 300 U/ml versus insulin glargine 100 U/ml in people with type 2 diabetes using basal insulin and oral antihyperglycaemic drugs: the EDITION 2 randomized 12-month trial including 6-month extension
Published in:
Diabetes, Obesity & Metabolism, 2015, v. 17, n. 12, p. 1142, doi. 10.1111/dom.12532
By:
- Yki‐Järvinen, H.;
- Bergenstal, R. M.;
- Bolli, G. B.;
- Ziemen, M.;
- Wardecki, M.;
- Muehlen‐Bartmer, I.;
- Maroccia, M.;
- Riddle, M. C.
Publication type:
Article
One-year sustained glycaemic control and less hypoglycaemia with new insulin glargine 300 U/ml compared with 100 U/ml in people with type 2 diabetes using basal plus meal-time insulin: the EDITION 1 12-month randomized trial, including 6-month extension.
Published in:
Diabetes, Obesity & Metabolism, 2015, v. 17, n. 9, p. 835, doi. 10.1111/dom.12472
By:
- Riddle, M. C.;
- Yki‐Järvinen, H.;
- Bolli, G. B.;
- Ziemen, M.;
- Muehlen‐Bartmer, I.;
- Cissokho, S.;
- Home, P. D.
Publication type:
Article
Patient-level meta-analysis of the EDITION 1, 2 and 3 studies: glycaemic control and hypoglycaemia with new insulin glargine 300 U/ml versus glargine 100 U/ml in people with type 2 diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2015, v. 17, n. 9, p. 859, doi. 10.1111/dom.12485
By:
- Ritzel, R.;
- Roussel, R.;
- Bolli, G. B.;
- Vinet, L.;
- Brulle‐Wohlhueter, C.;
- Glezer, S.;
- Yki‐Järvinen, H.
Publication type:
Article
Comparison of insulin glargine and liraglutide added to oral agents in patients with poorly controlled type 2 diabetes.
Published in:
Diabetes, Obesity & Metabolism, 2015, v. 17, n. 2, p. 170, doi. 10.1111/dom.12406
By:
- D'Alessio, D.;
- Häring, H.‐U.;
- Charbonnel, B.;
- de Pablos‐Velasco, P.;
- Candelas, C.;
- Dain, M.‐P.;
- Vincent, M.;
- Pilorget, V.;
- Yki‐Järvinen, H.
Publication type:
Article
Gene Expression and Immunohistochemistry in Adipose Tissue of HIV Type 1-Infected Patients with Nucleoside Analogue Reverse-Transcriptase Inhibitor-Associated Lipoatrophy.
Published in:
Journal of Infectious Diseases, 2009, v. 200, n. 2, p. 252, doi. 10.1086/599986
By:
- Sievers, M.;
- Walker, U. A.;
- Sevastianova, K.;
- Setzer, B.;
- Wågsäter, D.;
- Eriksson, P.;
- Yki-Järvinen, H.;
- Sutinen, J.
Publication type:
Article
Insulin Sensitivity Regulates Autonomic Control of Heart Rate Variation Independent of Body Weight in Normal Subjects.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2001, v. 86, n. 3, p. 1403, doi. 10.1210/jc.86.3.1403
By:
- BERGHOLM, R.;
- WESTERBACKA, J.;
- VEHKAVAARA, S.;
- SEPPÄLÄ -LINDROOS, A.;
- GOTO, T.;
- YKI-JÄRVINEN, H.
Publication type:
Article
Mechanisms of Altered Hemodynamic and Metabolic Responses to Insulin in Patients with Insulin-Dependent Diabetes Mellitus and Autonomic Dysfunction.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1998, v. 83, n. 2, p. 468, doi. 10.1210/jc.83.2.468
By:
- MÄKIMATTILA, S.;
- MÄNTYSAARI, M.;
- SCHLENZKA, A.;
- SUMMANEN, P.;
- YKI-JÄRVINEN, H.
Publication type:
Article
Pathogenesis and prevention of the dawn phenomenon in diabetic patients treated with CSII.
Published in:
1986
By:
- Koivisto, Veikko A.;
- Yki-Järvinen, Hannele;
- Helve, Eero;
- Karonen, Sirkka-Liisa;
- Pelkonen, Risto;
- Koivisto, V A;
- Yki-Järvinen, H;
- Helve, E;
- Karonen, S L;
- Pelkonen, R
Publication type:
journal article
Effects of body composition on insulin sensitivity.
Published in:
1983
By:
- Yki-Järvinen, Hannele;
- Koivisto, Veikko A.;
- Yki-Järvinen, H;
- Koivisto, V A
Publication type:
journal article
FAILURE TO SUPPRESS C-PEPTIDE SECRETION BY EUGLYCAEMIC HYPERINSULINAEMIA: A NEW DIAGNOSTIC TEST FOR INSULINOMA?
Published in:
Clinical Endocrinology, 1985, v. 23, n. 4, p. 461, doi. 10.1111/j.1365-2265.1985.tb01104.x
By:
- YKI-JÄRVINEN, H.;
- PELKONEN, R.;
- KOIVISTO, V. A.
Publication type:
Article
Pregnancy Proteins in the Endometrium after Follicle Aspiration for in Vitro Fertilizationa.
Published in:
Annals of the New York Academy of Sciences, 1985, v. 442, n. 1, p. 402, doi. 10.1111/j.1749-6632.1985.tb37546.x
By:
- WAHLSTRÖM, T.;
- KOSKIMIES, A. I.;
- TENHUNEN, A.;
- RUTANEN, E.-M.;
- YKI-JäRVINEN, H.;
- JULKUNEN, M.;
- SJÖBERG, J.;
- SEPPäLä, M.
Publication type:
Article
Acute and Chronic Effects of Hyperglycaemia on Glucose Metabolism: Implications for the Development of New Therapies.
Published in:
Diabetic Medicine, 1997, v. 14, n. S3, p. S32, doi. 10.1002/(SICI)1096-9136(199708)14:3+<S32::AID-DIA442>3.0.CO;2-6
By:
- Yki-Järvinen, H.
Publication type:
Article
CB(1) blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans.
Published in:
2013
By:
- Bergholm, R;
- Sevastianova, K;
- Santos, A;
- Kotronen, A;
- Urjansson, M;
- Hakkarainen, A;
- Lundbom, J;
- Tiikkainen, M;
- Rissanen, A;
- Lundbom, N;
- Yki-Järvinen, H
Publication type:
journal article
CB1 blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans.
Published in:
International Journal of Obesity, 2013, v. 37, n. 5, p. 699, doi. 10.1038/ijo.2012.116
By:
- Bergholm, R;
- Sevastianova, K;
- Santos, A;
- Kotronen, A;
- Urjansson, M;
- Hakkarainen, A;
- Lundbom, J;
- Tiikkainen, M;
- Rissanen, A;
- Lundbom, N;
- Yki-Järvinen, H
Publication type:
Article
Management of Type 2 Diabetes Mellitus and Cardiovascular Risk: Lessons from Intervention Trials.
Published in:
Drugs, 2000, v. 60, n. 5, p. 975, doi. 10.2165/00003495-200060050-00001
By:
- Yki-Järvinen, H.
Publication type:
Article
Metformin Prevents Weight Gain by Reducing Dietary Intake During Insulin Therapy in Patients with Type 2 Diabetes Mellitus.
Published in:
Drugs, 1999, v. 58, n. 6, p. 53, doi. 10.2165/00003495-199958001-00012
By:
- Yki-Järvinen, H.;
- Nikkilä, K.;
- Mäkimattila, S.
Publication type:
Article
Comparison of bedtime insulin regimens in patients with type 2 diabetes mellitus. A randomized, controlled trial.
Published in:
1999
By:
- Yki-Jarvinen H;
- Ryysy L;
- Nikkila K;
- Tulokas T;
- Vanamo R;
- Heikkila M;
- Yki-Järvinen, H;
- Ryysy, L;
- Nikkilä, K;
- Tulokas, T;
- Vanamo, R;
- Heikkilä, M
Publication type:
journal article
Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups.
Published in:
2007
By:
- Yki-Järvinen H;
- Juurinen L;
- Alvarsson M;
- Bystedt T;
- Caldwell I;
- Davies M;
- Lahdenperä S;
- Nijpels G;
- Vähätalo M
Publication type:
Journal Article
Improvement of glycemic control by 1 year of insulin therapy leads to a sustained decrease in sE-selectin concentrations in type 2 diabetes.
Published in:
2001
By:
- Ryysy, L;
- Yki-Järvinen, H
Publication type:
journal article
Predictors of abnormal cardiovascular autonomic function measured by frequence domain analysis of heart rate variability and conventional tests in patients with type 1 diabetes.
Published in:
2000
By:
- Mäkimattila, S;
- Schlenzka, A;
- Mäntysaari, M;
- Bergholm, R;
- Summanen, P;
- Saar, P;
- Erkkilä, H;
- Yki-Järvinen, H
Publication type:
journal article
Assessment of insulin secretion from the oral glucose tolerance test in white patients with type 2 diabetes.
Published in:
2000
By:
- STUMVOLL, MICHAEL;
- MITRAKOU, ASIMINA;
- PIMENTA, WALKYRIA;
- JENSSEN, TROND;
- YKI-JÄRVINEN, HANNELE;
- VAN HAEFTEN, TIMON;
- HÄRING, HANS;
- FRITSCHE, ANDREAS;
- GERICH, JOHN;
- Stumvoll, M;
- Mitrakou, A;
- Pimenta, W;
- Jenssen, T;
- Yki-Järvinen, H;
- Van Haeften, T;
- Häring, H;
- Fritsche, A;
- Gerich, J
Publication type:
Letter
Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group.
Published in:
2000
By:
- Yki-Järvinen, H;
- Dressler, A;
- Ziemen, M;
- HOE 901/300s Study Group
Publication type:
journal article
Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity.
Published in:
2000
By:
- Stumvoll, Michael;
- Mitrakou, Asimina;
- Pimenta, Walkyria;
- Jenssen, Trond;
- Yki-Jarvinen, Hannele;
- Van Haeften, Timon;
- Renn, Walter;
- Gerich, John;
- Stumvoll, M;
- Mitrakou, A;
- Pimenta, W;
- Jenssen, T;
- Yki-Järvinen, H;
- Van Haeften, T;
- Renn, W;
- Gerich, J
Publication type:
journal article
Normalization of insulin sensitivity in type I diabetic subjects by physical training during insulin pump therapy.
Published in:
1984
By:
- Yki-Järvinen, Hannele;
- DeFronzo, Ralph A.;
- Koivisto, Veikko A.;
- Yki-Järvinen, H;
- DeFronzo, R A;
- Koivisto, V A
Publication type:
journal article
Insulin therapy in type 2 diabetes: role of the long-acting insulin glargine analogue.
Published in:
European Journal of Clinical Investigation, 2004, v. 34, n. 6, p. 410, doi. 10.1111/j.1365-2362.2004.01356.x
By:
- Yki-Järvinen, H.
Publication type:
Article
Comparison of in vivo effects of nitroglycerin and insulin on the aortic pressure waveform.
Published in:
European Journal of Clinical Investigation, 2004, v. 34, n. 1, p. 1, doi. 10.1111/j.1365-2362.2004.01283.x
By:
- Westerbacka, J.;
- Tamminen, M.;
- Cockcroft, J.;
- Yki-Järvinen, H.
Publication type:
Article
Insulin therapy improves insulin actions on glucose metabolism and aortic wave reflection in type 2 diabetic patients.
Published in:
European Journal of Clinical Investigation, 2003, v. 33, n. 10, p. 855, doi. 10.1046/j.1365-2362.2003.01220.x
By:
- Tamminen, M. K.;
- Westerbacka, J.;
- Vehkavaara, S.;
- Yki-Järvinen, H.
Publication type:
Article
Low HDL cholesterol concentration is associated with increased intima-media thickness independent of arterial stiffness in healthy subjects from families with low HDL cholesterol.
Published in:
European Journal of Clinical Investigation, 2003, v. 33, n. 6, p. 457, doi. 10.1046/j.1365-2362.2003.01165.x
By:
- Alagona, C.;
- Soro, A.;
- Westerbacka, J.;
- Ylitalo, K.;
- Salonen, J.T.;
- Salonen, R.;
- Yki-Järvinen, H.;
- Taskinen, M.-R.
Publication type:
Article
Resistance to exercise-induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with type 1 diabetes.
Published in:
2001
By:
- Peltoniemi, Pauliina;
- Yki-Jarvinen, Hannele;
- Oikonen, Vesa;
- Oksanen, Airi;
- Takala, Teemu O.;
- Ronnemaa, Tapani;
- Erkinjuntti, Matti;
- Knuuti, M. Juhani;
- Nuutila, Pirjo;
- Peltoniemi, P;
- Yki-Järvinen, H;
- Oikonen, V;
- Oksanen, A;
- Takala, T O;
- Rönnemaa, T;
- Erkinjuntti, M;
- Knuuti, M J;
- Nuutila, P
Publication type:
journal article
Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.
Published in:
2000
By:
- Ryysy, Leena;
- Hakkinen, Anna-Maija;
- Goto, Takashi;
- Vehkavaara, Satu;
- Westerbacka, Jukka;
- Halavaara, Juha;
- Yki-Jarvinen, Hannele;
- Ryysy, L;
- Häkkinen, A M;
- Goto, T;
- Vehkavaara, S;
- Westerbacka, J;
- Halavaara, J;
- Yki-Järvinen, H
Publication type:
journal article

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