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- Title
Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib.
- Authors
Christodoulou, Michael S.; Mori, Mattia; Pantano, Rebecca; Alfonsi, Romina; Infante, Paola; Botta, Maurizio; Damia, Giovanna; Ricci, Francesca; Sotiropoulou, Panagiota A.; Liekens, Sandra; Botta, Bruno; Passarella, Daniele
- Abstract
The design and the preparation of a small library of 1,4-diphenyl-1,2,3-triazole derivatives is reported, with the aim to obtain a new class of Hedgehog pathway inhibitors. The smoothened protein is part of the hedgehog signaling pathway that is inhibited by the lead compound Vismodegib. Based on molecular modeling simulations, seven triazole derivatives of Vismodegib are synthesized and their biological effect on different endothelial, cancer, and cancer stem cell lines is reported.
- Subjects
DIPHENYL; TRIAZOLES; HEDGEHOGS; CHEMICAL inhibitors; MOLECULAR models; TRIAZOLE derivatives; STEM cells
- Publication
ChemPlusChem, 2015, Vol 80, Issue 6, p938
- ISSN
2192-6506
- Publication type
Article
- DOI
10.1002/cplu.201402435