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- Title
C<sub>60</sub> fullerene reduces the level of fluctuations in the force response of muscle gastrocnemius in chronically alcoholized rats.
- Authors
Motuziuk, Olexandr; Nozdrenko, Dmytro; Prylutska, Svitlana; Bogutska, Kateryna; Mishchenko, Iryna; Abramchuk, Olga; Khrapatyi, Sergii; Ritter, Uwe; Prylutskyy, Yuriy
- Abstract
The biomechanical parameters of muscle gastrocnemius contraction and biochemical parameters of blood and muscle tissue in rats after chronic alcoholization for 3, 6, and 9 months were studied. The oral administration of C60 fullerene aqueous solution (C60FAS) at doses of 0.5, 1, and 2 mg/kg throughout the experiment was used as a therapeutic agent. C60FAS in each of the experimental groups was administered in three ways: 1 h before alcohol intake, together with alcohol, and 1 h after alcohol intake. The most significant positive effects were recorded when alcohol and C60FAS were administered together at the optimal dose of 1 mg/kg. So, the increase in muscle gastrocnemius contraction force was 20 ± 1%, 33 ± 2% and 65 ± 3% (p < 0.05) compared with control at 3, 6, and 9 months alcoholization, respectively, as well as a high level of its fluctuations correction was observed throughout the experiment. Biochemical parameters such as blood levels of creatinine, creatine phosphokinase, lactate and lactate dehydrogenase as well as pro- and antioxidant balance (content of hydrogen peroxide and reduced glutathione, as well as catalase, selenium-dependent glutathione peroxidase and superoxide dismutase activities) in muscle gastrocnemius tissues decreased from 15 ± 2% (3 months of alcoholization) to 45 ± 2% (9 months of alcoholization) (p < 0.05) compared to controls. The results indicate promising prospects for the use of water-soluble C60 fullerenes, as powerful antioxidants, for the correction of pathological conditions of the muscular system arising from alcohol intoxication.
- Subjects
SKELETAL muscle; ORAL drug administration; CREATINE kinase; GLUTATHIONE peroxidase; ALCOHOLIC intoxication; MUSCLES
- Publication
Applied Nanoscience, 2023, Vol 13, Issue 10, p7057
- ISSN
2190-5509
- Publication type
Article
- DOI
10.1007/s13204-023-02874-7