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- Title
Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis.
- Authors
Alevizos, Ilias; Mahadevappa, Mamatha; Zhang, Xue; Ohyama, Hiroe; Kohno, Yohko; Posner, Marshall; Gallagher, George T; Varvares, Mark; Cohen, Donald; Kim, Dae; Kent, Ralph; Donoff, R Bruce; Todd, Randy; Yung, Chou Ming; Warrington, Janet A; Wong, David T W
- Abstract
Large scale gene expression profiling was carried out on laser capture microdissected (LCM) tumor and normal oral epithelial cells and analysed on high-density oligonucleotide microarrays. About 600 genes were found to be oral cancer associated. These oral cancer associated genes include oncogenes, tumor suppressors, transcription factors, xenobiotic enzymes, metastatic proteins, differentiation markers, and genes that have not been implicated in oral cancer. The database created provides a verifiable global profile of gene expression during oral carcinogenesis, revealing the potential role of known genes as well as genes that have not been previously implicated in oral cancer. Oncogene (2001) 20, 6196–6204.
- Subjects
ORAL cancer; GENE expression; MICRODISSECTION; DNA microarrays
- Publication
Oncogene, 2001, Vol 20, Issue 43, p6196
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1204685