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- Title
Acute generalized exanthematous pustulosis: clinical characteristics, etiologic associations, treatments, and outcomes in a series of 28 patients at Mayo Clinic, 1996-2013.
- Authors
Alniemi, Dema T.; Wetter, David A.; Bridges, Alina G.; el‐Azhary, Rokea A.; Davis, Mark D. P.; Camilleri, Michael J.; McEvoy, Marian T.
- Abstract
Background Acute generalized exanthematous pustulosis ( AGEP) is a rare skin condition typically caused by medications. The objective of this study was to examine the clinical features, causes, and outcomes of AGEP at a sole tertiary care center. Methods A retrospective review of patients with AGEP (European Study of Severe Cutaneous Adverse Reactions score of ≥ 5) seen at Mayo Clinic (Rochester, MN, USA) between January 1, 1996, and December 31, 2013, was conducted. Results Of 28 patients (mean age at onset: 56 years), 17 (61%) were women. The development of AGEP was attributed to medications in 25 patients (89%), with clindamycin the most common culprit (six patients). Three patients (11%) had mucous membrane involvement, and 21 (75%) showed systemic involvement. Ten patients (36%) received systemic corticosteroids for treatment of AGEP. Skin findings resolved within 15 days in 26 patients (93%) (mean time to resolution: 7.6 days). In three patients (11%), generalized skin eruptions or dermatitis developed weeks to months after the resolution of AGEP. Twenty-four patients (86%) had a personal history of drug reactions before the development of AGEP. Conclusions A previous history of drug reactions and clindamycin causation were more common in the present cohort than in prior reports. A small subset of patients experienced new-onset non- AGEP skin eruptions within a few months of the resolution of AGEP.
- Subjects
SKIN abnormalities; CLINDAMYCIN; MUCOUS membranes; ADRENOCORTICAL hormones; SKIN inflammation; NEUTROPHILS; TOXIC epidermal necrolysis
- Publication
International Journal of Dermatology, 2017, Vol 56, Issue 4, p405
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/ijd.13434