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- Title
JS-K activates G2/M checkpoints through the DNA damage response and induces autophagy via CAMKKβ/AMPKα/mTOR pathway in bladder cancer cells.
- Authors
Yuwan Zhao; Shanhong Lin; Wenfeng Zeng; Xinghua Lin; Xingzhang Qin; Bailiang Miu; Sheng Gao; Haokai Wu; Jianjun Liu; Xiaojun Chen
- Abstract
This article, published in the Journal of Cancer, examines the impact of JS-K, a nitric oxide prodrug, on bladder cancer cells. The study reveals that low concentrations of JS-K hindered the growth of bladder cancer cells while leaving normal cells unaffected. JS-K induced DNA damage in bladder cancer cells and impeded DNA damage repair. It also triggered a block in the G2/M phase and calcium overload, activating the CAMKKß/AMPK¿/mTOR pathway, which led to autophagy. These findings suggest that JS-K holds promise as an anti-tumor drug for bladder cancer.
- Subjects
BLADDER cancer genetics; DNA damage; AUTOPHAGY; BLADDER cancer treatment; BLADDER cancer diagnosis
- Publication
Journal of Cancer, 2024, Vol 15, Issue 2, p343
- ISSN
1837-9664
- Publication type
Article
- DOI
10.7150/jca.86393