We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
STUDY ON HEMOGLOBINOPATHIES IN ANEMIC PATIENTS IN A TERTIARY HOSPITAL OF JHARKHAND.
- Authors
Nazish, Shaoor; Shankar, Ravi; Prasad, Raj Kumar; kumar, Alok
- Abstract
Background: Hemoglobinopathies represent a group of genetic disorders characterized by abnormal hemoglobin production, posing significant clinical and diagnostic challenges. High-Performance Liquid Chromatography (HPLC) has emerged as a reliable tool for the characterization of hemoglobin variants, offering insights into the clinical implications of different genetic mutations. Objectives: This study aims to utilize HPLC to characterize hemoglobin variants and analyze their clinical significance in various hemoglobinopathies. Materials and Methods: Patients presenting with suspected hemoglobinopathies were recruited for the study. Hemoglobin variants were characterized using HPLC, and their clinical implications were assessed. Data were analyzed using appropriate statistical methods to determine the prevalence and clinical significance of different hemoglobin variants. Results: Distinct hematological profiles were observed in patients with different hemoglobinopathies. β-thalassemia major/intermedia exhibited significantly lower hemoglobin levels and altered RBC indices, while sickle cell disease manifested moderate anemia and characteristic abnormalities in RBC morphology. β-thalassemia trait showed microcytic hypochromic features, whereas Hb D Punjab Sickle cell variant exhibited elevated hemoglobin levels alongside abnormal RBC indices. Conclusion: The findings of this study highlight the clinical significance of precise hemoglobin characterization using HPLC in various hemoglobinopathies. Accurate diagnosis and tailored management strategies are essential for improving patient outcomes in hemoglobinopathy care. Continued research in this area is warranted to further enhance our understanding of hemoglobinopathies and optimize diagnostic and therapeutic approaches.
- Subjects
JHARKHAND (India); HEMOGLOBIN polymorphisms; HEMOGLOBINOPATHY; SICKLE cell anemia; HIGH performance liquid chromatography; HOSPITAL patients; GENETIC disorders
- Publication
International Journal of Medicine & Public Health, 2024, Vol 14, Issue 1, p271
- ISSN
2230-8598
- Publication type
Article
- DOI
10.5530/ijmedph.2024.1.52