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- Title
Role of autophagy related Gene 16 L1 in psoriasis pathogenesis.
- Authors
Naguib, Rehab Mohamed; El-Rifaie, Abd-El Aziz; Eissa, Eman Abdel Zaher; Rashed, Laila Ahmed
- Abstract
Background Psoriasis is a chronic hyperproliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Autophagy is a strictly regulated lysosomal degradation pathway that is crucial for maintaining intracellular homeostasis and normal development. The dysregulation of autophagy-associated genes was recognized to increase the susceptibility to multiple diseases, including inflammation, autoimmune disorders, and cancer. Objective Our study aimed to detect the expression of autophagy related gene 16 L 1(ATG 16L) in psoriasis patients compared to normal control persons to investigate the possible role of autophagy in pathogenesis of this disease. Methods This case - control study included thirty psoriasis patients and thirty healthy controls. Four mm punch skin biopsies were obtained from psoriasis lesions and from the controls and they were kept in lysis solution for the stability of the studied parameters and were kept frozen at -80 Celsius till analysis of ATG 16L using real time polymerase chain reaction. Results The level of autophagy related gene 16 L1 in lesional skin of psoriasis was significantly increased compared to normal control persons (p<0.001). Conclusion Autophagy may play a role in the pathogenesis of psoriasis disease.
- Subjects
AUTOPHAGY; PSORIASIS; PSORIATIC arthritis; POLYMERASE chain reaction; AUTOIMMUNE diseases; DISEASE susceptibility
- Publication
Journal of Pakistan Association of Dermatologists, 2021, Vol 31, Issue 4, p637
- ISSN
1560-9014
- Publication type
Case Study