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- Title
The Role of Partial Enteral Nutrition for Induction of Remission in Crohn's Disease: A Systematic Review of Controlled Trials.
- Authors
González-Torres, Lucía; Moreno-Álvarez, Ana; Fernández-Lorenzo, Ana Estefanía; Leis, Rosaura; Solar-Boga, Alfonso
- Abstract
Exclusive enteral nutrition (EEN) is recommended as a first-line therapy to induce remission of Crohn's disease (CD) and is considered as effective as corticosteroid treatment. However, the dietary restriction causes lack of adherence and poor tolerance to the therapy. Partial enteral nutrition (PEN), which allows for the ingestion of some food, could be a better tolerated alternative, but it is unknown whether it is as effective at inducing CD remission as EEN. The aim of this systematic review is to analyze the available evidence on PEN as a remission induction therapy in CD. A literature search was conducted using the MEDLINE (via PUBMED) and Cochrane Library databases following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Clinical trials in pediatric and adult patients were included. The risk of bias was assessed following the Cochrane Collaboration methodology. The selected studies showed variable but high response rates to PEN and EEN. Limitations regarding the wide heterogeneity between the studies included in this review should be considered. Although more studies are needed, according to our results, PEN combined with a highly restrictive diet seems to be as effective as EEN in inducing remission of CD.
- Subjects
CROHN'S disease; ONLINE information services; MEDICAL databases; SYSTEMATIC reviews; EVIDENCE-based medicine; DESCRIPTIVE statistics; ENTERAL feeding; MEDLINE
- Publication
Nutrients, 2022, Vol 14, Issue 24, p5263
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14245263