We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Supplementation of Lycium barbarum Polysaccharide Combined with Aerobic Exercise Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis via AMPK/PPARα/PGC-1α Pathway.
- Authors
Li, Dou-Dou; Ma, Jia-Min; Li, Ming-Jing; Gao, Lu-Lu; Fan, Yan-Na; Zhang, Yan-Nan; Tao, Xiu-Juan; Yang, Jian-Jun
- Abstract
Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease (NAFLD). Either Lycium barbarum polysaccharide (LBP) or aerobic exercise (AE) has been reported to be beneficial to hepatic lipid metabolism. However, whether the combination of LBP with AE improves lipid accumulation of NASH remains unknown. Our study investigated the influence of 10 weeks of treatment of LBP, AE, and the combination (LBP plus AE) on high-fat-induced NASH in Sprague–Dawley rats. The results showed that LBP or AE reduced the severity of the NASH. LBP plus AE treatment more effectively ameliorated liver damage and lowered levels of serum lipid and inflammation. In addition, the combination can also regulate genes involved in hepatic fatty acid synthesis and oxidation. LBP plus AE activated AMPK, thereby increasing the expression of PPARα which controls hepatic fatty acid oxidation and its coactivator PGC-1α. Our study demonstrated the improvement of LBP plus AE on NASH via enhancing fatty acid oxidation (FAO) which was dependent on AMPK/PPARα/PGC-1α pathway.
- Subjects
LIPID metabolism; INFLAMMATION prevention; THERAPEUTIC use of plant extracts; POLYSACCHARIDES; MEDICINAL plants; AEROBIC exercises; ANTILIPEMIC agents; NUCLEAR proteins; ANIMAL experimentation; NON-alcoholic fatty liver disease; PEROXISOME proliferator-activated receptors; DIETARY supplements; CELLULAR signal transduction; RATS; EDIBLE plants; TREATMENT effectiveness; GENE expression; COMBINED modality therapy; DIETARY fats; LIPIDS; FATTY acids; OXIDATION-reduction reaction; EVALUATION
- Publication
Nutrients, 2022, Vol 14, Issue 15, p3247
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14153247