We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats.
- Authors
Michicotl-Meneses, Maria Monica; Thompson-Bonilla, María del Rocío; Reyes-López, César A.; García-Pérez, Blanca Estela; López-Tenorio, Itzel I.; Ordaz-Pichardo, Cynthia; Jaramillo-Flores, María Eugenia
- Abstract
Pomegranate juice (Punica granatum) has been used since ancient times in traditional medicine (Unani Medicine, Ayurveda); its main compounds are anthocyanins and ellagic acid, which have anti-inflammatory, antioxidant, hepatoprotective, and cardiovascular health effects. The objective was to evaluate the effect of pomegranate juice on inflammation, blood pressure, and vascular and physiological markers associated with obesity induced by a high-fat diet in a murine model. The results show that pomegranate juice reduces the concentration of low-density lipoprotein cholesterol (cLDL) 39% and increases the concentration of high-density lipoprotein cholesterol (cHDL) by 27%, leading to a 12%–18% decrease in the risk of cardiovascular diseases (CVD). In addition to reducing blood pressure by 24%, it also had an antiatherogenic effect by decreasing sE-selectin levels by 42%. On the other hand, the juice significantly increased adiponectin levels in adipose tissue, decreased levels of inflammation markers (tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1 (PAI-1), interleukin-17A (IL-17A), interleukin-6 (IL-6), interleukin-1β (IL-1β)), and inhibited the monocyte chemoattractant protein-1 (MCP-1). Pomegranate juice requires clinical studies to prove its immunoregulatory and therapeutic effects on cardiovascular and atherogenic risks.
- Subjects
BIOMARKERS; CARDIOVASCULAR diseases risk factors; OBESITY; INTERLEUKINS; CYTOKINES; POMEGRANATE; INFLAMMATION; ANIMAL experimentation; DIET; INGESTION; LOW density lipoproteins; RATS; TUMOR necrosis factors; PLASMINOGEN activators; ADIPOSE tissues
- Publication
Nutrients, 2021, Vol 13, Issue 8, p2577
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13082577