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- Title
Nutrition Support in Liver Transplantation and Postoperative Recovery: The Effects of Vitamin D Level and Vitamin D Supplementation in Liver Transplantation.
- Authors
Doi, Junshi; Moro, Amika; Fujiki, Masato; Eghtesad, Bijan; Quintini, Cristiano; Menon, K. V. Narayanan; Hashimoto, Koji; Sasaki, Kazunari
- Abstract
Vitamin D plays an important role in the arena of liver transplantation. In addition to affecting skeletal health significantly, it also clinically exerts immune-modulatory properties. Vitamin D deficiency is one of the nutritional issues in the perioperative period of liver transplantation (LT). Although vitamin D deficiency is known to contribute to higher incidences of acute cellular rejection (ACR) and graft failure in other solid organ transplantation, such as kidneys and lungs, its role in LT is not well understood. The aim of this study was to investigate the clinical implication of vitamin D deficiency in LT. LT outcomes were reviewed in a retrospective cohort of 528 recipients during 2014–2019. In the pre-transplant period, 55% of patients were vitamin-D-deficient. The serum vitamin D level was correlated with the model for end-stage liver disease (MELD-Na) score. Vitamin D deficiency in the post-transplant period was associated with lower survival after LT, and the post-transplant supplementation of vitamin D was associated with a lower risk of ACR. The optimal vitamin D status and vitamin D supplementation in the post-transplant period may prolong survival and reduce ACR incidence.
- Subjects
THERAPEUTIC use of vitamin D; CONVALESCENCE; DIET therapy; DIETARY supplements; GRAFT rejection; LIVER failure; LIVER transplantation; POSTOPERATIVE period; RISK assessment; SERUM; TRANSPLANTATION of organs, tissues, etc.; VITAMIN D; VITAMIN D deficiency; TREATMENT effectiveness; RETROSPECTIVE studies
- Publication
Nutrients, 2020, Vol 12, Issue 12, p3677
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12123677