We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype.
- Authors
Lope, Virginia; Guerrero-Zotano, Ángel; Casas, Ana; Baena-Cañada, José Manuel; Bermejo, Begoña; Pérez-Gómez, Beatriz; Criado-Navarro, Inmaculada; Antolín, Silvia; Sánchez-Rovira, Pedro; Ramos-Vázquez, Manuel; Antón, Antonio; Castelló, Adela; García-Saénz, José Ángel; Muñoz, Montserrat; de Juan, Ana; Andrés, Raquel; Llombart-Cussac, Antonio; Hernando, Blanca; Franquesa, Rosa María; Caballero, Rosalia
- Abstract
This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30–0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49–0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48–0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20–2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12–2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14–2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45–2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.
- Subjects
BREAST tumor risk factors; BREAST tumors; CANCER patients; CONFIDENCE intervals; FATTY acids; GAS chromatography; MASS spectrometry; MEDICAL cooperation; MENOPAUSE; PHOSPHOLIPIDS; QUESTIONNAIRES; RESEARCH; RISK assessment; TUMOR markers; LINOLEIC acid; MULTIPLE regression analysis; BODY mass index; LIFESTYLES; CASE-control method; DESCRIPTIVE statistics; ODDS ratio
- Publication
Nutrients, 2020, Vol 12, Issue 10, p3132
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12103132