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- Title
Antiangiogenic Therapy a Two-Trick Pony?
- Authors
Hampton, Tracy
- Abstract
Discusses antiangiogenic therapy. Failure of the therapy to combat established tumors in humans by blocking formation of new blood vessels to bring oxygen and nutrients to tumors; Claim by Rakesh K. Jain of the Massachusetts General Hospital in Boston that this therapeutic failure is not surprising; Suggestion that another effect of antiangiogenic agents might be useful in treating cancer; Potential for such agents to provide a way to allow more efficient delivery of cytotoxic cancer agents to the tumor; Challenge to combining antiangiogenic therapy with chemotherapy or radiation in that antiangiogenic drugs kill the very blood vessels needed to deliver oxygen and drugs to the tumor, and oxygen is a requirement for radiation to work; Counterintuitive finding that antiangiogenic therapies do potentiate the effects of radiation and chemotherapy.
- Subjects
CANCER treatment; TUMORS; BLOOD vessels; CELL-mediated cytotoxicity; ANTINEOPLASTIC agents; OXYGEN; ONCOLOGY; DRUG therapy; RADIATION; JAIN, Rakesh K.
- Publication
JAMA: Journal of the American Medical Association, 2005, Vol 293, Issue 9, p1051
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.293.9.1051