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- Title
Adenovirus type-2 in a patient with lethal hemorrhagic colonic ulcers and chronic active Epstein-Barr virus infection.
- Authors
Okano, Motohiko; Thiele, Geoffrey M.; Davis, Jack R.; Nauseef, William M.; Mitros, Frank; Purtilo, David T.; Okano, M; Thiele, G M; Davis, J R; Nauseef, W M; Mitros, F; Purtilo, D T
- Abstract
An adenovirus type-2 was isolated from peripheral blood lymphocytes and throat washings from a patient with severe chronic active Epstein-Barr virus infection. Despite the Epstein-Barr virus reactivation, attempts to establish spontaneous lymphoblastoid cell lines from peripheral blood lymphocytes and to immortalize cord lymphocytes with throat washings were unsuccessful due to a marked cytopathic effect. The supernatants from the cultures induced cytopathic effect in cultured cord lymphocytes, MRC-5 cells, A-549 cells, or Vero cells. Virus particles with adenovirus morphology were seen by electron microscopy. Using type-specific antisera, the isolate was identified as adenovirus type-2. In addition, both Epstein-Barr virus and adenovirus type-2 genomes were seen in the colonic tissues and spleen. These results suggest that the combination of Epstein-Barr virus and adenovirus type-2 may be etiologic agents in the development of chronic active Epstein-Barr virus infection in this patient.
- Subjects
ADENOVIRUSES; EPSTEIN-Barr virus
- Publication
Annals of Internal Medicine, 1988, Vol 108, Issue 5, p693
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-108-5-693