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- Title
Chronic Epstein-Barr virus infection associated with fever and interstitial pneumonitis. Clinical and serologic features and response to antiviral chemotherapy.
- Authors
Schooley, Robert T.; Carey, Robert W.; Miller, George; Henle, Werner; Eastman, Robin; Mark, Eugene J.; Kenyon, Kenneth; Wheeler, Edwin O.; Rubin, Robert H.; Schooley, R T; Carey, R W; Miller, G; Henle, W; Eastman, R; Mark, E J; Kenyon, K; Wheeler, E O; Rubin, R H
- Abstract
Two patients developed fever, interstitial pneumonitis, and pancytopenia associated with extremely high titers of antibody to replicative antigens of the Epstein-Barr virus. In contrast to most patients seropositive for Epstein-Barr virus, neither patient had an antibody response to the Epstein-Barr nuclear antigen K polypeptide. In addition, virus isolated from one patient had a deletion of the B95-8 type in the EcoRI C region of the genome. An etiologic relation between Epstein-Barr virus replication and the clinical manifestations of this syndrome is further shown by the response of each patient to acyclovir therapy. These patients have a new Epstein-Barr-virus-associated syndrome and provide additional evidence that acyclovir may play a role in therapy for selected patients with Epstein-Barr virus infection.
- Subjects
EPSTEIN-Barr virus diseases; PNEUMONIA; FEVER; DISEASES in teenagers
- Publication
Annals of Internal Medicine, 1986, Vol 104, Issue 5, p636
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-104-5-636