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- Title
Accuracy of aMMP-8 point-of- care test in indicating periodontal treatment outcomes in stage III/IV periodontitis: A 24-week follow-up study.
- Authors
Yilmaz, Mustafa; Sorsa, Timo; Demir, Esra; Gürsoy, Mervi; Suominen, Auli; Tervahartiala, Taina; Räisänen, Ismo T.; Gürsoy, Ulvi K.
- Abstract
Objective: To analyse the correspondence between aMMP-8 PoC test results and the clinical endpoints of non-surgical periodontal treatment in stage III/IV periodontitis. Background: The diagnostic success of the active-matrix metalloproteinase-8 (aMMP-8) point-of- care (PoC) test has been demonstrated in various studies, but the evidence of its accuracy following periodontal treatment is limited. Materials and methods: Altogether 42 stage III/IV grade C periodontitis patients were included in this prospective diagnostic study. Clinical periodontal indices were recorded, aMMP-8 PoC test was applied and mouthrinse was collected before and at 6, 12 and 24 weeks after non-surgical periodontal treatment. Quantitative aMMP-8 levels were determined with immunofluorometric assay (IFMA) for the verification of the PoC test results. The accuracy of the aMMP-8 PoC test was assessed using previously established clinical endpoints as references. Results: Sensitivity and specificity of aMMP-8 PoC test to indicate clinical endpoints were ranged as follows: Sensitivity 71.4% at baseline, 39.3%–42.4% at week 6, 28.6%–32.4% at week 12 and 35.3%–42.9% at week 24; specificity 64.3%–80% at week 6, 40%–57.1% at week 12 and 56%–64.3% at week 24. Conclusions: The accuracy of aMMP-8 PoC test in identifying clinical endpoints after non-surgical periodontal treatment is reduced in relation to baseline. Individual healing patterns of each diseased pocket eventually limit the accuracy of the dichotomous aMMP-8 oral rinse test during the post-treatment period.
- Subjects
TURKEY; PERIODONTITIS treatment; ACADEMIC medical centers; PERIODONTITIS; POINT-of-care testing; MOUTHWASHES; FLUOROIMMUNOASSAY; QUANTITATIVE research; FISHER exact test; MATRIX metalloproteinases; TREATMENT effectiveness; INTRACLASS correlation; CHI-squared test; RESEARCH funding; SENSITIVITY &; specificity (Statistics); LONGITUDINAL method
- Publication
Journal of Periodontal Research, 2023, Vol 58, Issue 2, p325
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/jre.13093