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- Title
Atopic diseases/diathesis and subsequent ischemic stroke among patients with bipolar disorder: A nationwide longitudinal study.
- Authors
Chen, Li-Chi; Chen, Mu-Hong; Su, Tung-Ping; Tsai, Shih-Jen; Bai, Ya-Mei; Li, Cheng-Ta; Yang, Albert C.; Chang, Wen-Han; Chen, Tzeng-Ji
- Abstract
Introduction: Previous studies have suggested that both bipolar disorder and atopy are associated with an increased risk of stroke. However, the role of atopic diseases/diathesis in the risk of stroke among patients with bipolar disorder remains unclear. Methods: Using Taiwan’s National Health Insurance Research Database, we selected 55,593 patients with bipolar disorder between 2002 and 2008, divided them into patients with atopic diseases/diathesis (n = 21,050) and patients without atopic diseases/diathesis (n = 34,543), and observed them until the end of 2011. Patients who experienced a stroke during the follow-up period were identified. Results: Patients with bipolar disorder and atopic diseases/diathesis had an elevated risk of ischemic stroke (hazard ratio [HR]: 1.44, 95% confidence interval [CI]: 1.25–1.59) compared with patients with only bipolar disorder; a dose-dependent relationship was observed between the number of allergic comorbidities and the risk of ischemic stroke (1 atopic disease, HR: 1.30, 95% CI: 1.13–1.49; 2 atopic diseases, HR: 1.59, 95% CI: 1.33–1.91; ≥ 3 atopic diseases, HR: 2.09, 95% CI: 1.50–2.91).The role of atopic diseases in the risk of hemorrhagic stroke among patients with bipolar disorder was nonsignificant (HR: 0.84, 95% CI: 0.64–1.09). Conclusions: Patients with bipolar disorder and atopic diseases/diathesis are more prone to ischemic stroke later in life than are those without atopic diseases/diathesis. Further study is required to investigate the underlying mechanism linking atopy, bipolar disorder, and stroke.
- Subjects
TAIWAN; DISEASE susceptibility; BIPOLAR disorder; STROKE risk factors; IMMUNE system; PUBLIC health
- Publication
PLoS ONE, 2018, Vol 13, Issue 8, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0200682