We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Metamorphosis increases biotransformation of polychlorinated biphenyls: A comparative study of polychlorinated biphenyl metabolism in green frogs (Rana clamitans) and leopard frogs (Rana pipiens) at various life stages.
- Authors
Leney, Jocelyn L.; Drouillard, Ken G.; Haffner, G. Douglas
- Abstract
Polychlorinated biphenyl (PCB) elimination rates were used to determine whether green frogs (Rana clamitans) and leopard frogs (Rana pipiens) at three life stages (tadpole, metamorph, and adult) were capable of metabolic biotransformation of PCBs. Polychlorinated biphenyls were grouped according to their structural properties to determine whether congeners with specific structures were eliminated more rapidly than others, which would suggest the occurrence of metabolic biotransformation. For both species and at all life stages studied, PCBs with adjacent unsubstituted meta-para sites (group-2 PCBs) were eliminated significantly faster than PCBs with adjacent unsubstituted ortho-meta sites (group-3 PCBs). Because these groups of PCBs span similar hydrophobicity ranges, it was concluded that green and leopard frogs can selectively metabolize group-2 PCBs. Metabolic activity was more pronounced in the metamorph stage than in any other life stage. In green frog metamorphs, the average elimination rate of the group-2 PCBs was 4.9-fold greater than that of the group-3 PCBs. By contrast, in green frog tadpoles, group-2 PCBs were eliminated 1.9-fold faster than group-3 PCBs, and in green frog adults, group-2 PCBs were eliminated 1.5-fold faster than group-3 PCBs.
- Subjects
POLYCHLORINATED biphenyls; BIOTRANSFORMATION (Metabolism); AMPHIBIAN metamorphosis; NORTHERN leopard frog; GREEN frog; ANIMAL life cycles
- Publication
Environmental Toxicology & Chemistry, 2006, Vol 25, Issue 11, p2971
- ISSN
0730-7268
- Publication type
Article
- DOI
10.1897/05-561R1.1