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- Title
Children Born With Congenital Zika Syndrome Display Atypical Gross Motor Development and a Higher Risk for Cerebral Palsy.
- Authors
Marques, Fernanda J. P.; Teixeira, Marta C. S.; Barra, Rafael R.; de Lima, Fernanda M.; Dias, Bruno L. Scofano; Pupe, Camila; Nascimento, Osvaldo J. M.; Leyser, Marcio
- Abstract
Importance: Congenital Zika syndrome virus infection is said to interfere in children's development. Objective: evaluate gross motor trajectories and the frequency of cerebral palsy in children with congenital Zika syndrome. Design: Cohort study applying the Alberta Infant Motor Scale (AIMS) and the Bayley III Scales in infants from 6 to 18 months of age. Setting: The SARAH network, Rio de Janeiro. Participants: Thirty-nine infants whose diagnoses were established through clinical history, serology tests, and neuroimaging findings. Main outcomes and measures: Congenital Zika syndrome is associated with severe motor delays and is a risk factor to the diagnosis of cerebral palsy. Results: The Alberta Infant Motor Scale mean raw score at 6 months was 9.74 (SD 4.80) or equivalent to 2 to 3 months of motor developmental age. At the age of 12 months, 14.13 (SD 11.90), corresponding to 3 to 4 months of motor development age; the Bayley III Scales results correlated to the Alberta Infant Motor Scale (P < .001) at this age. At 18 months, 15.77 (SD 13.80) or a motor development equivalent to 4 to 5 months of age. Thirty-five of 39 children (89.7%) met criteria for the diagnosis of cerebral palsy. Conclusions and relevance: Gross motor development marginally progresses from 6 to 18 months of age. These individuals also displayed a high frequency of cerebral palsy.
- Subjects
ZIKA virus infections; CHILDREN'S health; DISEASE prevalence; CEREBRAL palsy; BRAIN imaging
- Publication
Journal of Child Neurology, 2019, Vol 34, Issue 2, p81
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073818811234