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- Title
The alterations of cardiac function during venovenous artificial placenta support in fetal goats.
- Authors
Li, Guanhua; Li, Mingliang; Teng, Yun; Zhang, Li; Pang, Chengcheng; Tan, Jianfeng; Chen, Jimei; Zhuang, Jian; Zhou, Chengbin
- Abstract
Introduction: Venovenous artificial placenta (VVAP) may mimic the intrauterine environment for maintaining fetal circulation. However, changes in ventricular function in fetal goats undergoing VVAP support remain unclear. Methods: Pump-assisted VVAPs were established in five fetal goats for 9 h. The myocardial performance index (Tei index), cardiac output (CO), and blood biochemical parameters were measured during VVAP support. Results: An increasing trend of the right ventricular (RV) Tei index was seen during VVAP support (p for trend < 0.01). The right ventricular cardiac output (RVCO) increased after the initiation of VVAP, while a significant trend of reduction was observed after 3 h (p for trend = 0.03). During VVAP support, we observed remarkable elevations of plasma cTnI and arterial lactic acid, which were positively correlated with the RV Tei index, but not the left ventricular (LV) Tei index, LVCO, and RVCO. Conclusions: The RVCO increases initially while a tendency of decrease could be observed during VVAP support. Special attention should be paid to right ventricular dysfunction during VVAP support.
- Publication
International Journal of Artificial Organs, 2024, Vol 47, Issue 1, p17
- ISSN
0391-3988
- Publication type
Article
- DOI
10.1177/03913988231215905