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- Title
High‐Frequency Ultrasound for Evaluation of the Pathological Invasion Level of Extramammary Paget Disease.
- Authors
Ma, Yuan‐Yuan; Gong, Xue‐Hao; Wang, Qiao; Wang, Li‐Fan; Xu, Hui‐Xiong; Guo, Le‐Hang
- Abstract
Objectives: Pathological invasion level of extramammary Paget disease (EMPD) is strongly related with its risk staging, treatment, and prognosis. However, the current evaluation before treatments fails to evaluate pathological invasion level of EMPD. High‐frequency ultrasound (HFUS) may play a key role to solve this problem. The purpose was to explore the performance of HFUS in the evaluation of pathological invasion level of EMPD. Methods: Sixty pathologically proven EMPD patients were retrospectively enrolled and divided into 2 groups as follows: in situ in the epidermis (IE) (n = 42) and invasion into the dermis or subcutaneous (ID) (n = 18) groups. Clinical and HFUS features were compared between the 2 groups. Results: Between the 2 groups, HFUS features (lesion shape, internal echogenicity and echotexture, surface shape, epidermal hyperechoic layer on the surface, the "pseudopod sign", and color Doppler ultrasound features) and clinical features were comparable (all P >.05). Tumor growth pattern significantly differed between the 2 groups (P <.05). Infiltration depth was significantly deeper for the ID group than the IE group (P <.05). With a cutoff value of 1.55 mm for infiltration depth, the area under the receiver operating characteristic curve was 0.833. Conclusions: HFUS features of tumor growth pattern and infiltration depth may contribute to the assessment of invasion level of EMPD. Access the CME test here and search by article title.
- Subjects
RECEIVER operating characteristic curves; DOPPLER ultrasonography; ULTRASONIC imaging; CONTRAST-enhanced ultrasound
- Publication
Journal of Ultrasound in Medicine, 2022, Vol 41, Issue 2, p389
- ISSN
0278-4297
- Publication type
Article
- DOI
10.1002/jum.15716