We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26.CoV2.S Vaccination in People Living With Human Immunodeficiency Virus (HIV).
- Authors
Khan, Khadija; Lustig, Gila; Bernstein, Mallory; Archary, Derseree; Cele, Sandile; Karim, Farina; Smith, Muneerah; Ganga, Yashica; Jule, Zesuliwe; Reedoy, Kajal; Miya, Yoliswa; Mthabela, Ntombifuthi; Magula, Nombulelo P; Lessells, Richard; Oliveira, Tulio de; Gosnell, Bernadett I; Karim, Salim Abdool; Garrett, Nigel; Hanekom, Willem; Bekker, Linda-Gail
- Abstract
Background People living with HIV (PLWH) have been reported to have a higher risk of more severe COVID-19 disease and death. We assessed the ability of the Ad26.CoV2.S vaccine to elicit neutralizing activity against the Delta variant in PLWH relative to HIV-negative individuals. We also examined effects of HIV status and suppression on Delta neutralization response in SARS-CoV-2—infected unvaccinated participants. Methods We enrolled participants who were vaccinated through the SISONKE South African clinical trial of the Ad26.CoV2.S vaccine in healthcare workers (HCWs). PLWH in this group had well-controlled HIV infection. We also enrolled unvaccinated participants previously infected with SARS-CoV-2. Neutralization capacity was assessed by a live virus neutralization assay of the Delta variant. Results Most Ad26.CoV2.S vaccinated HCWs were previously infected with SARS-CoV-2. In this group, Delta variant neutralization was 9-fold higher compared with the infected-only group and 26-fold higher relative to the vaccinated-only group. No decrease in Delta variant neutralization was observed in PLWH relative to HIV-negative participants. In contrast, SARS-CoV-2—infected, unvaccinated PLWH showed 7-fold lower neutralization and a higher frequency of nonresponders, with the highest frequency of nonresponders in people with HIV viremia. Vaccinated-only participants showed low neutralization capacity. Conclusions The neutralization response of the Delta variant following Ad26.CoV2.S vaccination in PLWH with well-controlled HIV was not inferior to HIV-negative participants, irrespective of past SARS-CoV-2 infection. In SARS-CoV-2—infected and nonvaccinated participants, HIV infection reduced the neutralization response to SARS-CoV-2, with the strongest reduction in HIV viremic individuals.
- Subjects
SOUTH Africa; HIV-positive persons; COVID-19; COVID-19 vaccines; NEUTRALIZATION tests; VIREMIA; MIXED infections
- Publication
Clinical Infectious Diseases, 2022, Vol 75, Issue 1, pe857
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciab1008