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- Title
Discovery of Half-life of Circulating Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B Infection Using Heavy Water Labeling.
- Authors
Loomba, Rohit; Decaris, Martin; Li, Kelvin W; Shankaran, Mahalakshmi; Mohammed, Hussein; Matthews, Marcy; Richards, Lisa M; Nguyen, Phirum; Rizo, Emily; Andrews, Barbara; Soto, Robin; Angel, Thomas; Suri, Vithika; Kitrinos, Kathryn M; Barnes, Dwight; Czerwieniec, Gregg; Brendza, Kathy; Subramanian, G Mani; Gaggar, Anuj; Hellerstein, Marc K
- Abstract
In a pilot study, heavy water labeling was used to determine hepatitis B surface antigen (HBsAg) turnover rates in chronic hepatitis B (CHB) patients. The mean (standard deviation) half-life of HBsAg in blood was 6.7 (5.5) days, which reflects recent production in the liver and supports strategies aimed at reducing HBsAg production in CHB patients.
- Subjects
ANTIGENS; DRUG labeling; HYDROGEN; ISOTOPES; MASS spectrometry; TIME; PILOT projects; DESCRIPTIVE statistics; CHRONIC hepatitis B
- Publication
Clinical Infectious Diseases, 2019, Vol 69, Issue 3, p542
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciy1100