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- Title
Chemical Probes for Drug-Resistance Assessment by Binding Competition (RABC): Oseltamivir Susceptibility Evaluation.
- Authors
Cheng, Ting‐Jen R.; Wang, Shi‐Yun; Wen, Wen‐Hsien; Su, Ching‐Yao; Lin, Mengi; Huang, Wen‐I; Liu, Ming‐Tsan; Wu, Ho‐Sheng; Wang, Nung‐Sen; Cheng, Chung‐Kai; Chen, Chun‐Lin; Ren, Chien‐Tai; Wu, Chung‐Yi; Fang, Jim‐Min; Cheng, Yih‐Shyun E.; Wong, Chi‐Huey
- Abstract
The wizard of OS (resistance): The binding difference of neuraminidase inhibitors (zanamivir versus oseltamivir (OS)) was used to establish an assay to identify the influenza subtypes that are resistant to OS but still sensitive to zanamivir (see scheme). This assay used a zanamivir‐biotin conjugate to determine the OS susceptibility of a wide range of influenza viruses and over 200 clinical isolates.
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 1, p366
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201204062