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- Title
Cohesin: a critical chromatin organizer in mammalian gene regulation.
- Authors
Chien, Richard; Zeng, Weihua; Ball, Alexander R.; Yokomori, Kyoko
- Abstract
Cohesins are evolutionarily conserved essential multi-protein complexes that are important for higher-order chromatin organization. They play pivotal roles in the maintenance of genome integrity through mitotic chromosome regulation, DNA repair and replication, as well as gene regulation critical for proper development and cellular differentiation. In this review, we will discuss the multifaceted functions of mammalian cohesins and their apparent functional hierarchy in the cell, with particular focus on their actions in gene regulation and their relevance to human developmental disorders.
- Subjects
COHESINS; CHROMATIN; GENETIC regulation; MITOSIS; CHROMOSOMES; DNA repair; DNA replication
- Publication
Biochemistry & Cell Biology, 2011, Vol 89, Issue 5, p445
- ISSN
0829-8211
- Publication type
Article
- DOI
10.1139/o11-039