We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Is Vitamin D Deficiency a Risk Factor for the Development of Statin-Induced Myalgia in Patients Receiving Statins?
- Authors
TAŞOĞLU, Özlem; KUTSAL, Yeşim Gökçe; TAŞOĞLU, İrfan; ÖZDEMİR, Oya; ERDOĞANOĞLU, Yıldız
- Abstract
Objective: In recent years, discussions regarding the possibility of vitamin D deficiency playing a role in statin myopathy development have started. The purpose of this study is to determine whether or not there is a significant difference with respect to vitamin D levels and objective muscle strength measures in males with or without statin-induced myalgia. Material and Methods: This study includes 1 7 male patients with statin-induced myalgia and 23 male patients without statin-induced myalgia; the latter being matched with the former. 25-OH vitamin D levels of all patients were recorded. Body fat rates of the patients were studied with bio-impedance analysis. Visual analog scale and McGill-Melzack pain questionnaire were applied to the patients with myalgia. Gripping strength and isometric and isokinetic measurements on the biceps and quadriceps muscles of all patients were performed. Results: Mean vitamin D levels were above the sufficiency level in both of the groups, and there was no significant difference between them. When the measurements with the hand dynamometer and the isometric and isokinetic muscular strength analyses for both groups were compared, there was no statistically significant difference between them. Conclusion: In this study, it is demonstrated that vitamin D deficiency may not be a risk factor for the development of statin-induced myalgia; furthermore, there is no statistical difference between the objective muscle strength measures of male patients with or without statin-induced myalgia.
- Subjects
ADIPOSE tissues; EXERCISE tests; GRIP strength; BIOELECTRIC impedance; ISOKINETIC exercise; MUSCLE contraction; MYALGIA; QUESTIONNAIRES; REGRESSION analysis; STATISTICS; T-test (Statistics); VITAMIN D; VITAMIN D deficiency; STATINS (Cardiovascular agents); LOGISTIC regression analysis; DATA analysis; VISUAL analog scale; CROSS-sectional method; CASE-control method; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test; DISEASE complications; DISEASE risk factors
- Publication
Turkish Journal of Physical Medicine & Rehabilitation / Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi, 2015, Vol 61, Issue 4, p314
- ISSN
1302-0234
- Publication type
Article
- DOI
10.5152/tftrd.2015.86158