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- Title
Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterations.
- Authors
Bastie, Jean-Noël; Aucagne, Romain; Droin, Nathalie; Solary, Eric; Delva, Laurent
- Abstract
The relatively homogenous clinical features and poor prognosis of chronic myelomonocytic leukemia (CMML) are associated with a molecular heterogeneity, with various mutations impacting several convergent pathways. Due to the restricted understanding of the mechanism involved in leukemogenesis, CMML still appears as a diagnostic and therapeutic undertaking, and poor prognosis of leukemia. Contrary to chronic myelogenous leukemia, BCR- ABL1-positive, cytogenetic, and molecular abnormalities of CMML are not specific and not pathognomonic, confirming the different levels of heterogeneity of this disease. Various mutations can be associated with a common phenotype not distinct at the clinical level, further demonstrating that molecular probings are needed for choosing individual targeted therapies.
- Subjects
BIOMARKERS; MONOCYTIC leukemia; LEUKEMIA genetics; LEUKEMIA; SOMATIC mutation; LABORATORY mice; CYTOGENETICS; PROGNOSIS
- Publication
Cellular & Molecular Life Sciences, 2012, Vol 69, Issue 17, p2853
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-012-0956-y