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- Title
Expression and distribution of immunoglobulin G and its receptors in an immune privileged site: the eye.
- Authors
Niu, Na; Zhang, Jie; Sun, Yingui; Wang, Shuna; Sun, Yonghong; Korteweg, Christine; Gao, Weiwei; Gu, Jiang
- Abstract
It has recently been demonstrated that not only mature B lymphocytes, but also non-lymphoid cells, including cancer cells and neurons, express IgG. In the eye, an important immune privileged site, the presence of IgG has been ascribed to IgG entering the eye through breaches of the blood-ocular barrier. Here we demonstrate that the eye itself can produce IgG intrinsically. Applying immunohistochemistry, in situ hybridization, and RT-PCR, several intraocular structures were found to express proteins and mRNA transcripts of IgG heavy chains, light chains, V(D)J rearrangements, and enzymes required for V(D)J recombination. IgG receptors were also detected in the intraocular epithelium and endothelium. The extensive distribution of IgG and its receptors in intraocular structures indicates that locally produced IgG could play a significant role in maintaining the ocular microenvironment and protection of the eyes, and it might also be involved in the pathogenesis of age-related macular degeneration and some inflammatory diseases.
- Subjects
IMMUNOGLOBULIN G; CELL receptors; GENE expression; IRIDOCYCLITIS; RETINAL degeneration; B cells; CANCER cells; IMMUNOHISTOCHEMISTRY
- Publication
Cellular & Molecular Life Sciences, 2011, Vol 68, Issue 14, p2481
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-010-0572-7