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- Title
Down‐to‐Earth Studies of the Gut Microbiome in Bone Health and Disease.
- Authors
Li, Ruolin; Medina‐Gomez, Carolina; Rivadeneira, Fernando
- Abstract
In the last years, clinical trials of probiotics have reported positive effects for different types of I Lactobacillus spp i . on bone health outcomes, SP ( sp 1 SP ) sp both in humans (ie, I Lactobacillus rheuteri i and the combination of I Lactobacillus paracasei i DSM 13434, I Lactobacillus plantarum i DSM 15312, and I Lactobacillus plantarum i DSM 15313) and in animal models (ie, I Lactobacillus acidophilus i and I Lactobacillus rhamnosus i ). Therefore, the bench-to-bedside trajectory of gut microbiome research could benefit from the contribution of large epidemiological (observational) studies that can aid the understanding of the underlying biological mechanisms and, in theory, orient the design of interventional studies to successfully improve bone health. The gut microbiome is considered a key modulator of human health, with growing evidence for effects across multiple body systems and where skeletal health outcomes are no exception. SP ( sp 1 SP ) sp Hundreds of publications have emerged in the last years, extending from fundamental (in vitro and in vivo animal) studies to interventional trials (mostly focusing on probiotics and prebiotics), supporting a putative relationship between variation in the gut microbiome and bone metabolism. SP ( sp 2 SP ) sp Nevertheless, in what way the gut microbiome triggers bone disease remains to be clearly elucidated.
- Subjects
BONE health; GUT microbiome; PREBIOTICS; BONE diseases
- Publication
Journal of Bone & Mineral Research, 2022, Vol 37, Issue 4, p595
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1002/jbmr.4547