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- Title
Klotho Variants and Chronic Hemodialysis Mortality.
- Authors
Friedman, David J.; Afkarian, Maryam; Tamez, Hector; Bhan, Ishir; Isakova, Tamara; Wolf, Myles; Ankers, Elizabeth; Ye, Jun; Tonelli, Marcello; Zoccali, Carmine; Kuro-o, Makoto; Moe, 0rson; Karumanchi, S. Ananth; Thadhani, Ravi
- Abstract
The article presents a study which discussed the high mortality rates of patients with different Klotho gene variants undergoing chronic hemodialysis because of end-stage renal disease (ESRD). It is stated that CC genotype is associated with lower Klotho expression as compared with the AA/AC genotype. The findings of analysis after DNA extraction and single nucleotide polymorphisms (SNP) selection are revealed.
- Subjects
MORTALITY; HEMODIALYSIS; CHRONIC kidney failure; DNA; NUCLEOTIDES; GENETIC polymorphisms
- Publication
Journal of Bone & Mineral Research, 2009, Vol 24, Issue 11, p1846
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/JBMR.090516