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- Title
Cystic fibrosis-related diabetes: an update.
- Authors
Frost, F; Walshaw, M J; Nazareth, D
- Abstract
Cystic fibrosis (CF) is the most common life-threatening inherited condition in the Caucasian population, where mutations in the CF transmembrane conductance regulator gene result in a multifactorial syndrome, with pulmonary disease representing the largest contributor to morbidity and mortality. Life expectancy has improved and the recent development of disease-modifying CF transmembrane conductance regulator modulator therapies is likely to further improve survival. However, increasing life expectancy brings new challenges related to the complications of a chronic disease including an increasing prevalence of CF-related diabetes, itself associated with increased morbidity and early mortality. This review provides an update as regards the underlying mechanisms, investigation and management of CF-related diabetes.
- Subjects
CYSTIC fibrosis; REGULATOR genes; DIABETES; LIFE expectancy; DISEASE complications
- Publication
QJM: An International Journal of Medicine, 2022, Vol 115, Issue 9, p582
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcaa256