We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Naked Dense Bodies Provoke Depression.
- Authors
Hallermann, Stefan; ittel, Robert J.; Wichmann, Carolin; Weyhersmüller, Annika; Fouquet, Wernher; Mertel, Sara; Oswald, David; Eimer, Stefan; Depner, Harald; Schwärzel, Martin; Sigrist, Stephan J.; Heckmann, Manfred
- Abstract
At presynaptic active zones (AZs), the frequently observed tethering of synaptic vesicles to an electron-dense cytomatrix represents a process of largely unknown functional significance. Here, we identified a hypomorphic allele, brp nude lacking merely the last 1% of the C-terminal amino acids (17 of 1740) of the active zone protein Bruchpilot. In brp nude, electron-dense bodies were properly shaped, though entirely bare of synaptic vesicles. While basal glutamate release was unchanged, paired-pulse and sustained stimulation provoked depression. Furthermore, rapid recovery following sustained release was slowed. Our results causally link, with intramolecular precision, the tethering of vesicles at the AZ cytomatrix to synaptic depression.
- Subjects
SYNAPTIC vesicles; SENSES; AMINO acids; GLUTAMIC acid; NEUROTRANSMITTERS; PHYSIOLOGY
- Publication
Journal of Neuroscience, 2010, Vol 30, Issue 43, p14340
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2495-10.2010