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- Title
Vaccine Effectiveness Against Influenza Hospitalization and Emergency Department Visits in 2 A(H3N2) Dominant Influenza Seasons Among Children <18 Years Old—New Vaccine Surveillance Network 2016–2017 and 2017–2018.
- Authors
Kim, Sara S; Naioti, Eric A; Halasa, Natasha B; Stewart, Laura S; Williams, John V; Michaels, Marian G; Selvarangan, Rangaraj; Harrison, Christopher J; Staat, Mary A; Schlaudecker, Elizabeth P; Weinberg, Geoffrey A; Szilagyi, Peter G; Boom, Julie A; Sahni, Leila C; Englund, Janet A; Klein, Eileen J; Ogokeh, Constance E; Campbell, Angela P; Patel, Manish M; Network, New Vaccine Surveillance
- Abstract
Studies have shown egg-adaptive mutations in influenza vaccine strains that might have impaired protection against circulating A(H3N2) influenza viruses during the 2016–2017 and 2017–2018 seasons. We used the test-negative design and multivariable models to assess vaccine effectiveness against influenza-associated hospitalization and emergency department visits among children (<18 years old) during the 2016–2017 and 2017–2018 seasons. Effectiveness was 71% (95% confidence interval, 59%–79%), 46% (35%–55%), and 45% (33%–55%) against A(H1N1)pdm09, A(H3N2), and B viruses respectively, across both seasons. During high-severity seasons with concerns for vaccine mismatch, vaccination offered substantial protection against severe influenza outcomes requiring hospitalization or emergency department visits among children.
- Publication
Journal of Infectious Diseases, 2022, Vol 226, Issue 1, p91
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiab624