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- Title
Combination of Clofazimine and Atovaquone as a Potent Therapeutic Regimen for the Radical Cure of Babesia microti Infection in Immunocompromised Hosts.
- Authors
Tuvshintulga, Bumduuren; Sivakumar, Thillaiampalam; Nugraha, Arifin Budiman; Ahedor, Believe; Batmagnai, Enkhbaatar; Otgonsuren, Davaajav; Liu, MingMing; Xuan, Xuenan; Igarashi, Ikuo; Yokoyama, Naoaki
- Abstract
Human babesiosis caused by Babesia microti can be fatal in immunocompromised patients, and the currently used drugs are often ineffective. A recent study found that clofazimine clears B. microti Munich strain in immunocompromised mice. In the present study, we investigated the efficacies of clofazimine and 2-drug combinations involving clofazimine, atovaquone, and azithromycin against B. microti Peabody mjr strain in immunocompromised mice. Treatment with clofazimine alone, clofazimine plus azithromycin, and atovaquone plus azithromycin was ineffective and failed to eliminate the parasites completely, while a 44-day treatment with clofazimine plus atovaquone was highly effective and resulted in a radical cure.
- Subjects
MUNICH (Germany); IMMUNOCOMPROMISED patients; BABESIA; AZITHROMYCIN; BABESIOSIS
- Publication
Journal of Infectious Diseases, 2022, Vol 225, Issue 2, p238
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab537