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- Title
Respiratory Syncytial Virus Consortium in Europe (RESCEU) Birth Cohort Study: Defining the Burden of Infant Respiratory Syncytial Virus Disease in Europe.
- Authors
Wildenbeest, Joanne G; Zuurbier, Roy P; Korsten, Koos; Houten, Marlies A van; Billard, Marie N; Derksen-Lazet, Nicole; Snape, Matthew D; Drysdale, Simon B; Robinson, Hannah; Pollard, Andrew J; Heikkinen, Terho; Cunningham, Steve; Leach, Amanda; Martinón-Torres, Federico; Sánchez, Carmen Rodríguez-Tenreiro; Gómez-Carballa, Alberto; Bont, Louis J; Investigators, RESCEU; van Houten, Marlies A; Rodríguez-Tenreiro Sánchez, Carmen
- Abstract
<bold>Background: </bold>Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants worldwide. Although prematurity and cardiopulmonary disease are risk factors for severe disease, the majority of infants hospitalized with RSV are previously healthy. Various vaccines and therapeutics are under development and expected to be available in the near future. To inform the use of these new vaccines and therapeutics, it is necessary to determine the burden of RSV disease in Europe. We will prospectively follow-up a birth cohort to obtain incidence data on RSV acute respiratory tract infection (ARTI).<bold>Methods: </bold>Multicenter prospective study of a birth cohort consisting of 10 000 healthy infants, recruited during 3 consecutive years. RSV associated hospitalization in the first year of life will be determined by questionnaires and hospital chart reviews. A nested cohort of 1000 infants will be actively followed. In case of ARTI, a respiratory sample will be collected for RSV molecular diagnosis.<bold>Results: </bold>The primary outcome is the incidence rate of RSV-associated hospitalization in the first year of life. In the active cohort the primary outcome is RSV associated ARTI and MA-ARTI.<bold>Conclusions: </bold>We will provide key information to fill the gaps in knowledge about the burden of RSV disease in healthy infants.<bold>Clinical Trials Registration: </bold>NCT03627572.
- Subjects
EUROPE; RESPIRATORY syncytial virus infections; RESPIRATORY syncytial virus; DISEASE risk factors; COHORT analysis; CLINICAL trial registries; RESEARCH; VIRAL vaccines; RESEARCH methodology; RESPIRATORY infections; DISEASE incidence; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; HOSPITAL care; LONGITUDINAL method
- Publication
Journal of Infectious Diseases, 2020, Vol 222, pS606
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa310