We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of pregnancy on chronic urticaria: Results of the PREG‐CU UCARE study.
- Authors
Kocatürk, Emek; Al‐Ahmad, Mona; Krause, Karoline; Gimenez‐Arnau, Ana M.; Thomsen, Simon Francis; Conlon, Niall; Marsland, Alexander; Savk, Ekin; Criado, Roberta F.; Danilycheva, Inna; Fomina, Daria; Godse, Kiran; Khoshkhui, Maryam; Gelincik, Aslı; Degirmentepe, Ece Nur; Demir, Semra; Ensina, Luis Felipe; Kasperska‐Zajac, Alicja; Rudenko, Michael; Valle, Solange
- Abstract
Background: Chronic urticaria (CU) predominantly affects women, and sex hormones can modulate disease activity in female CU patients. As of now, the impact of pregnancy on CU is largely unknown. Aim: To analyze the course and features of CU during and after pregnancy. Patients and methods: PREG‐CU is an international, multicenter study of the Urticaria Centers of Reference and Excellence (UCARE) network. Data were collected via a 47‐item questionnaire completed by CU patients, who became pregnant within the last 3 years. Results: A total of 288 pregnancies of 288 CU patients from 13 countries were analyzed (mean age at pregnancy: 32.1 ± 6.1 years, duration of CU: 84.9 ± 74.5 months; CSU 66.9%, CSU + CIndU 20.3%, CIndU 12.8%).During pregnancy, 51.1% of patients rated their CU as improved, 28.9% as worse, and 20.0% as unchanged.CU exacerbations most commonly occurred exclusively during the third trimester (in 34 of 124 patients; 27.6%) or the first (28 of 124; 22.8%). The risk factors for worsening of CU during pregnancy were having mild disease and no angioedema before pregnancy, not taking treatment before pregnancy, CIndU, CU worsening during a previous pregnancy, treatment during pregnancy, and stress as a driver of exacerbations. After giving birth, urticaria disease activity remained unchanged in 43.8% of CU patients, whereas 37.4% and 18.1% experienced worsening and improvement, respectively. Conclusions: These results demonstrate the complex impact of pregnancy on the course of CU and help to better counsel patients who want to become pregnant and to manage CU during pregnancy.
- Subjects
PREGNANCY; URTICARIA; SEX hormones; WOMEN patients; CURRICULUM
- Publication
Allergy, 2021, Vol 76, Issue 10, p3133
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.14950