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- Title
Management of poor-prognosis testicular germ cell tumors.
- Authors
Khurana, Kiranpreet; Gilligan, Timothy D.; Stephenson, Andrew J.
- Abstract
Currently, the outcome of patients with intermediate- and poor-risk germ cell tumors at diagnosis is optimized by the use of risk-appropriate chemotherapy and post-chemotherapy surgical resection of residual masses. Currently, there is no role for high-dose chemotherapy in the first-line setting. Patients who progress on first-line chemotherapy or who relapse after an initial complete response also have a poor prognosis. In the setting of early relapse, the standard approach at most centers is conventional-dose, ifosfamide-based regimens and post-chemotherapy resection of residual masses. The treatment of patients with late relapse is complete surgical resection whenever feasible. Salvage chemotherapy for late relapse may be used prior to surgery in patients where a complete resection is not feasible. A complete surgical resection of all residual sites of disease after chemotherapy is critical for the prevention of relapse and the long-term survival of patients with advanced germ cell tumors.
- Subjects
CANCER patient medical care; TESTIS tumors; GERM cells; CANCER chemotherapy; ANTINEOPLASTIC agents; SURGICAL excision; LYMPH node surgery; SALVAGE therapy
- Publication
Indian Journal of Urology, 2010, Vol 26, Issue 1, p108
- ISSN
0970-1591
- Publication type
Article