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- Title
Relationship to insulin resistance of the adult treatment panel III diagnostic criteria for identification of the metabolic syndrome.
- Authors
Cheal, Karen L.; Abbasi, Fahim; Lamendola, Cindy; McLaughlin, Tracey; Reaven, Gerald M.; Ford, Earl S.
- Abstract
The Adult Treatment Panel III (ATP III) has published criteria for diagnosing the metabolic syndrome, a cluster of closely related abnormalities related to insulin resistance that increase cardiovascular disease risk. The present analysis was performed to evaluate the ability of these criteria to identify insulin-resistant individuals. The population consisted of 443 healthy volunteers, with measurements of BMI, blood pressure, fasting plasma glucose, triglycerides, HDL cholesterol concentrations, and steady-state plasma glucose (SSPG) concentration. Insulin resistance was defined as being in the top tertile of SSPG concentrations. Of the population, 20% satisfied ATP III criteria for the metabolic syndrome. Although insulin resistance and the presence of the metabolic syndrome were significantly associated (P < 0.001), the sensitivity and positive predictive value equaled 46% (69 of 149) and 76% (69 of 91), respectively. Being overweight, with high triglycerides, low HDL cholesterol, or elevated blood pressure, most often resulted in a diagnosis of the metabolic syndrome. Thus, the ATP III criteria do not provide a sensitive approach to identifying insulin-resistant individuals. The individual components vary both in terms of their utility in making a diagnosis of the metabolic syndrome and their relationship to insulin resistance, with the obesity and lipid criteria being most useful.
- Subjects
INSULIN resistance; DIABETES complications; METABOLIC manifestations of general diseases; METABOLIC disorders; CARDIOVASCULAR diseases; DISEASE risk factors; OBESITY; BLOOD sugar
- Publication
Diabetes, 2004, Vol 53, Issue 5, p1195
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.53.5.1195