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- Title
Linkage analyses of the MODY3 locus on chromosome 12q with late-onset NIDDM.
- Authors
Lesage, Suzanne; Hani, El Habib; Philippi, Anne; Vaxillaire, Martine; Hager, Jörg; Passa, Philippe; Demenais, Florence; Froguel, Philippe; Vionnet, Nathalie; Lesage, S; Hani, E H; Philippi, A; Vaxillaire, M; Hager, J; Passa, P; Demenais, F; Froguel, P; Vionnet, N
- Abstract
Non-insulin-dependent diabetes mellitus (NIDDM) is a clinically and genetically heterogeneous disorder. Maturity-onset diabetes of the young (MODY), an autosomal dominant form of NIDDM, has been used as a model for genetic studies of NIDDM. We recently reported linkage between markers on chromosome 12q and diabetes in 25% of our French MODY families. To evaluate if this gene is also implicated in late-onset NIDDM, we performed linkage studies between two markers of the MODY region and diabetes in 172 families with late-onset NIDDM. Both parametric and nonparametric methods were used in a total of 600 affected sib-pairs. Linkage was rejected in this population by all methods, implying that the MODY gene on chromosome 12q is not a major gene for late-onset NIDDM in this population. However, we cannot exclude a modifying role in a polygenic disorder or an important role in some families.
- Publication
Diabetes, 1995, Vol 44, Issue 10, p1243
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.44.10.1243