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- Title
Effect of curcumin on the viability of SKOV3 cells and its probable mechanism of action.
- Authors
Wang Dan; Xu Cheng; Zhang Fei-Fei; Zeng Bao-Jin
- Abstract
Purpose: To study the influence of curcumin on the survival of SKOV3 cells and the potential molecular mechanism of action. Methods: SKOV3 cell proliferation was measured using MTT assay. Gene expression levels were assayed using QRT-PCR assay, while protein expression was determined with western blotting. Results: Cell viability was reduced by curcumin at doses of 20, 40 and 80 µM (p < 0.05) in a dosebased fashion. Protein expression levels of Bax, caspase-3 and caspase-9 were upregulated by curcumin, while Bcl-2 protein level was downregulated (p < 0.05). Conclusion: These results demonstrate that curcumin inhibits cell proliferation by promoting the protein expressions of pro-apoptotic genes (Bax, caspase-3 and caspase-9) while suppressing Bcl-2 protein level. Therefore, curcumin might be a novel alternative therapy for ovarian cancer.
- Subjects
CURCUMIN; INHIBITION of cellular proliferation; CELL survival; BCL-2 proteins; ALTERNATIVE treatment for cancer
- Publication
Tropical Journal of Pharmaceutical Research, 2021, Vol 20, Issue 4, p767
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v20i4.15