We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Anti-hepatitis B viral activity of Phyllanthus niruri L (Phyllanthaceae) in HepG2/C3A and SK-HEP-1 cells.
- Authors
Yong Li; Xin Li; Jia-Kun Wang; Yan Kuang; Ming-Xiu Qi
- Abstract
Purpose: To investigate the effectiveness of an ethanol extract of Phyllanthus niruri against hepatitis B viral (HBV) infection in human HepG2/C3A cells. Methods: An ellagic acid-rich ethanol fraction was obtained from P. niruri (Euphorbiaceae) by extraction and thin-layer chromatography. The anti-HBV activity of the fraction was evaluated in vitro against HepG2/C3A cells. The physicochemical characteristics of the fraction were assessed by nuclear magnetic resonance (1H and 12C-NMR). Results: The isolated active compound showed a half-maximal inhibitory concentration (IC50) of 120 μg/mL. Ellagic acid had no effect on HBV DNA replication at the concentrations evaluated, and did not inhibit the reproduction of HBV. However, the ethanol fraction inhibited the growth of HBV-infected HepG2/C3A cells. Conclusion: The findings suggest that the ethanol fraction of P. niruri inhibits HBV, and that the active component is not ellagic acid.
- Subjects
HEPATITIS B; PHYLLANTHUS; EUPHORBIACEAE; PHYLLANTHACEAE; ELLAGIC acid
- Publication
Tropical Journal of Pharmaceutical Research, 2017, Vol 16, Issue 8, p1873
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v16i8.17